Inflammatory and epithelial responses in mouse strains that differ in sensitivity to hyperoxic injury

Experimental Lung Research
C J JohnstonJ N Finkelstein

Abstract

The pulmonary response to various toxicants including bleomycin, ozone, ionizing radiation, and hyperoxia is highly variable among mouse strains. The current study tests the hypothesis that at a similar stage of injury, regardless of strain, expression of inflammatory cytokine and epithelial marker genes would be similar, indicating a common pathway of injury progression. Three strains of mice, C57B1/6J, 129/J, and C3H/HeJ, ranging from sensitive to resistant, were exposed to > 95% O2 for varying times. Ribonuclease protection was used to quantify changes in cytokine mRNA. Despite differences in the kinetics, each strain demonstrated similar hyperoxia-induced changes in the abundance of interleukin (IL)-6, IL-1 beta, IL-3, and tumor neucrosis factor (TNF)-alpha. For each strain, death was accompanied by similar increases in cytokine mRNAs above steady-state control levels. Other inflammatory cytokines, including IL-1 alpha, IL-4, and interferon (IFN)-gamma, were unaltered in all strains at all times. In situ hybridization analysis of the epithelial markers, surfactant protein B (SPB), and clara cell secretory protein (CCSP) at the time of proinflammatory induction showed a similar pattern of expression in all strains. Increased...Continue Reading

References

May 1, 1992·Journal of Applied Physiology·J C JensenJ A Norton
Jan 1, 1992·The American Journal of Physiology·K A WikenheiserJ A Whitsett
Aug 1, 1991·Journal of Applied Physiology·M F TsanJ E White
Feb 1, 1990·Journal of Applied Physiology·J T BergA E Taylor
Jun 1, 1990·The American Journal of Physiology·S R KleebergerR C Levitt
Apr 1, 1987·The American Journal of Physiology·Y ShikiI M Burr
Dec 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A MasudaK Matsushima
Jan 1, 1986·Annual Review of Physiology·J D Crapo
Jul 10, 1980·The New England Journal of Medicine·S M Deneke, B L Fanburg
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·L M CarlssonS L Marklund
Feb 1, 1994·American Journal of Respiratory Cell and Molecular Biology·B PiedboeufS Horowitz
Feb 1, 1994·American Journal of Respiratory Cell and Molecular Biology·Y Lewis-MolockC W White
Jun 1, 1993·Pharmacogenetics·B B HudakS R Kleeberger
Jan 1, 1993·The American Journal of Physiology·S R KleebergerL Y Zhang
Aug 1, 1997·American Journal of Respiratory Cell and Molecular Biology·C J JohnstonB R Stripp
Nov 14, 1997·Experimental Lung Research·C J JohnstonJ N Finkelstein

❮ Previous
Next ❯

Citations

Sep 27, 2006·Immunogenetics·Gregory S WhiteheadDavid A Schwartz
Apr 1, 2001·Avian Pathology : Journal of the W.V.P.A·S M JaenschS R Raidal
Feb 21, 2006·Antioxidants & Redox Signaling·Yan WangAron B Fisher
Sep 23, 2003·Infection and Immunity·James M BeckRobert Paine
Aug 15, 2009·American Journal of Respiratory and Critical Care Medicine·Narsa M ReddySekhar P Reddy
Apr 27, 2000·American Journal of Respiratory Cell and Molecular Biology·C Barazzone, C W White
Apr 18, 2001·American Journal of Respiratory Cell and Molecular Biology·H KobayashiR C Jones
Jun 21, 2001·American Journal of Respiratory Cell and Molecular Biology·M A O'ReillyP C Keng
Dec 26, 2001·American Journal of Respiratory Cell and Molecular Biology·Hye-Youn ChoSteven R Kleeberger
Oct 14, 2005·Proceedings of the American Thoracic Society·Claudette M St CroixBruce R Pitt
Feb 11, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Madah Khawn-I-Muhammad MehdiDavid Hicks
Nov 10, 2009·Experimental Lung Research·Akinori NagatoSamuel Santos Valenca
Aug 4, 2009·Toxicology and Applied Pharmacology·Hye-Youn Cho, Steven R Kleeberger
Mar 31, 2007·Seminars in Radiation Oncology·James BrushWilliam H McBride
Mar 23, 2004·Annals of the New York Academy of Sciences·Alessandra Pagano, Constance Barazzone-Argiroffo
May 23, 2014·Pediatric Pulmonology·Echezona T MaduekweMichael A O'Reilly
Nov 6, 2004·Free Radical Biology & Medicine·Yan WangAron B Fisher
Jun 20, 2006·Free Radical Biology & Medicine·Vineet Bhandari, Jack A Elias
Jan 7, 2000·The American Journal of Pathology·R J MasonJ M Shannon
Jun 30, 2004·Radiation Research·William H McBrideYu-Pei Liao
Jan 28, 2003·American Journal of Obstetrics and Gynecology·Irina A BuhimschiCarl P Weiner
Mar 1, 2016·The Journal of Pathology·Teruhiko SatoMarc G Achen
Apr 12, 2016·Journal of Cellular Physiology·Ivan Bertoncello
Oct 31, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Miguel A Alejandre-AlcázarRory E Morty
Mar 27, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Susan D ReynoldsBarry R Stripp
Apr 3, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rayman Choo-WingVineet Bhandari
Aug 14, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Thomas Hill Iii, Rory B Conolly
May 13, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jason M RoperMichael A O'Reilly
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vineet BhandariJack A Elias
Nov 15, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·T YanoJ M Shannon
Oct 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·C Barazzone-ArgiroffoP F Piguet
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Penelope RiceJeffrey D Hasday
Jan 18, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jason M RoperMichael A O'Reilly
Aug 12, 1998·The American Journal of Physiology·G W MangoB R Stripp
Oct 12, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jessica Berger, Vineet Bhandari
Oct 27, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Biji MathewJeffrey R Jacobson
Jan 5, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·M A O'ReillyG S Pryhuber
Mar 27, 2021·Frontiers in Medicine·Luciano AmarelleLeonel Malacrida
May 22, 2003·The American Journal of Pathology·Jeffrey D HasdayRose M Viscardi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.