PMID: 11921664Mar 30, 2002Paper

Inflammatory and immune processes: the neglected villain of bioprosthetic degeneration?

Journal of Long-term Effects of Medical Implants
Paul Human, Peter Zilla

Abstract

In an attempt to avoid the destructive process of bioprosthetic heart-valve calcification associated with the use of glutaraldehyde, valves are today prepared using low concentrations of the crosslinking reagent. In this review, we summarize our findings and those of others that confirm that the immunogenicity of such tissue is not sufficiently masked and that a defined humoral response is indeed mounted against a repertoire of antigens unrelated to those associated with vascularized and non-cross-linked xenograft organs. We demonstrate the need for increased cross-linking of tissue to satisfactorily mitigate that response; furthermore, we examine the impact of increased cross-link density on the macrophage as antigen presenting cell with respect to its involvement in both tissue erosion and pannus overgrowth. Finally we present evidence for a role of circulating antibodies in bioprosthesis calcification.

Citations

May 9, 2008·Regenerative Medicine·Francesco MignecoRavi K Birla
Jun 5, 2001·The Annals of Thoracic Surgery·A Trantina-YatesP Zilla
Apr 15, 2014·The Annals of Thoracic Surgery·Siamak MohammadiFrançois Dagenais
Dec 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Nermine LilaAlain Carpentier
Jun 3, 2008·Biomaterials·Leigh G GriffithsE Christopher Orton
Apr 29, 2008·Biomaterials·David F Williams
Oct 24, 2007·Biomaterials·Peter ZillaDeon Bezuidenhout
Jun 30, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Vincent M FriebeNaren R Vyavahare
Aug 23, 2012·Xenotransplantation·Filippo NasoGino Gerosa
Sep 5, 2012·Xenotransplantation·Hendrik J Ankersmit
Sep 15, 2014·The Journal of Thoracic and Cardiovascular Surgery·Christian P BrizardWilliam M L Neethling
Sep 8, 2005·Biomaterials·Joshua J LovekampNarendra R Vyavahare
Sep 10, 2016·Xenotransplantation·Eliran Moshe ReuvenVered Padler-Karavani
Jul 1, 2004·Journal of Biomedical Materials Research. Part a·Rachit OhriCecilia M Giachelli
Jul 12, 2018·Advanced Healthcare Materials·Francesca TaraballiEnnio Tasciotti
Jan 23, 2010·Clinical Genetics·C M Condit
Sep 10, 2003·Human Fertility : Journal of the British Fertility Society·Matt J Tomlinson, Allan A Pacey
Oct 31, 2019·Tissue Engineering. Part B, Reviews·Manuela Lopera Higuita, Leigh G Griffiths

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