Aug 1, 1989

Inflammatory and immunomodulatory roles of TGF-beta

Immunology Today
S M WahlS E Mergenhagen

Abstract

Transforming growth factors (TGFs) are small polypeptides that were initially defined by their ability to induce transformation of non-neoplastic cells in culture. However, it has become increasingly clear that TGFs are not restricted in function to promoting cell growth. One type of transforming growth factor, TGF-beta, is a multifunctional molecule which has unique and potent effects on many target cells and tissues. In this article, Sharon Wahl, Nancy McCartney-Francis and Stephan Mergenhagen focus on the evolving role of TGF-beta in regulating inflammation, immune responses and tissue repair.

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Mentioned in this Paper

Recombinant Transforming Growth Factor
Immune Response
Transforming Growth Factor beta
SPI1
Recombinant Transforming Growth Factor-Beta
Cell Growth
Pathologic Neovascularization
TGFB1 gene
TGFB1
Target Cell Count

About this Paper

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