Inflammatory and oxidative mechanisms potentiate bifenthrin-induced neurological alterations and anxiety-like behavior in adult rats

Toxicology Letters
Brahim GargouriHamadi Fetoui

Abstract

Bifenthrin (BF) is a synthetic pyrethroid pesticide widely used in several countries to manage insect pests on diverse agricultural crops. Growing evidence indicates that BF exposure is associated with an increased risk of developing neurodegenerative disorders. However, the mechanisms by which BF induces neurological and anxiety alterations in the frontal cortex and striatum are not well known. The present in vivo study was carried out to determine whether reactive oxygen species (ROS)-mediated oxidative stress (OS) and neuroinflammation are involved in such alterations. Thirty-six Wistar rats were thus randomly divided into three groups and were orally administered with BF (0.6 and 2.1 mg/kg body weight, respectively) or the vehicle (corn oil), on a daily basis for 60 days. Results revealed that BF exposure in rats enhanced anxiety-like behavior after 60 days of treatment, as assessed with the elevated plus-maze test by decreases in the percentage of time spent in open arms and frequency of entries into these arms. BF-treated rats also exhibited increased oxidation of lipids and carbonylated proteins in the frontal cortex and striatum, and decreased glutathione levels and antioxidant enzyme activities including superoxide dis...Continue Reading

Citations

Jun 15, 2019·Acta Neuropathologica·Jason R RichardsonAnumantha G Kanthasamy
Nov 23, 2018·Environmental Science and Pollution Research International·Anouar FerianiMohamed Salah Allagui
Dec 17, 2020·International Journal of Environmental Research and Public Health·Barbara Nieradko-Iwanicka, Michał Konopelko
Mar 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Waleed El MalekyHekma A Abd El-Latif
Apr 28, 2021·BMC Pharmacology & Toxicology·Oktawia Pylak-Piwko, Barbara Nieradko-Iwanicka
Jul 14, 2021·Neuroscience Letters·Nara Rubia D BernardinaGirlandia A Brasil
Dec 4, 2019·Journal of Agricultural and Food Chemistry·Changsheng WeiTaiyong Yu
Sep 10, 2020·Environmental Science & Technology·Jason MagnusonDaniel Schlenk

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