Inflammatory and oxidative stress-related effects associated with neurotoxicity are maintained after exclusively prenatal trichloroethylene exposure

Neurotoxicology
Sarah J BlossomCraig A Cooney

Abstract

Trichloroethylene (TCE) is a widespread environmental toxicant with immunotoxic and neurotoxic potential. Previous studies have shown that continuous developmental exposure to TCE encompassing gestation and early life as well as postnatal only exposure in the drinking water of MRL+/+ mice promoted CD4+ T cell immunotoxicity, glutathione depletion and oxidative stress in the cerebellum, as well increased locomotor activity in male offspring. The purpose of this study was to characterize the effects of exclusively prenatal exposure on these parameters. Another goal was to investigate potential plasma oxidative stress/inflammatory biomarkers to possibly be used as predictors of TCE-mediated neurotoxicity. In the current study, 6 week old male offspring of dams exposed gestationally to 0, 0.01, and 0.1mg/ml TCE in the drinking water were evaluated. Our results confirmed that the oxidized phenotype in plasma and cerebellum was maintained after exclusively prenatal exposure. A Phenotypic analysis by flow cytometry revealed that TCE exposure expanded the effector/memory subset of peripheral CD4+ T cells in association with increased production of pro-inflammatory cytokines IFN-γ and IL-17. Serum biomarkers of oxidative stress and infl...Continue Reading

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Citations

Oct 13, 2017·Toxicology and Industrial Health·Jia-Xiang ZhangQi-Xing Zhu
Aug 23, 2017·Immunopharmacology and Immunotoxicology·Josue D OrdazJoseph M K Irudayaraj
Apr 19, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sarah J BlossomKathleen M Gilbert
Jan 31, 2020·Environmental Science. Processes & Impacts·Briana R De Miranda, J Timothy Greenamyre
Jul 26, 2018·Frontiers in Pharmacology·Mohamed M SalamaSeham A G Elhak

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