Inflammatory angiomyolipomas of the liver: a clinicopathologic and immunohistochemical analysis of 5 cases

Annals of Diagnostic Pathology
Huaiyin ShiAitao Guo

Abstract

Hepatic angiomyolipoma (AML) may demonstrate a marked histologic diversity. We report 5 cases of hepatic AML exhibiting prominent inflammatory cells in the background (inflammatory AML). The patients were 4 females and 1 male, with age ranged from 21 to 48 years (mean, 39.2 years). Three tumors were in the left lobe and 2 in the right lobe. The tumor size was from 5.5 to 10 cm in the greatest dimension (mean, 7.46 cm). No patient had clinical features of tuberous sclerosis. Histologically, the striking feature was the infiltration of numerous inflammatory cells in the background of the tumors, including small lymphocytes, plasma cells, and histiocytes. The percentage of tumor area with heavy inflammatory infiltration was more than 50% in all cases. The myoid cells were spindled and epithelioid in shape, with eosinophilic or clear cytoplasm, and were arranged in fascicles and clusters. Scattered adipose cells and sinusoidal and thick-walled blood vessels were variably present in all tumors. Focal trabecular arrangement was present in 2 of the 5 tumors. There was no nuclear atypia, and mitotic figures were rare. The myoid cells were diffusely positive for vimentin, smooth muscle actin, and HMB-45 in all cases. All patients showed...Continue Reading

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Sep 18, 2012·Diagnostic Pathology·Yang LiuEn-Hua Wang
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Sep 5, 2020·Archives of Pathology & Laboratory Medicine·Raul S GonzalezAaron Auerbach
Jun 1, 2021·Annals of Hepato-biliary-pancreatic Surgery·Geunhyeok YangSeung-Mo Hong

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