Inflammatory Biomarkers and Risk of Schizophrenia: A 2-Sample Mendelian Randomization Study.

JAMA Psychiatry
Fernando Pires HartwigGeorge Davey Smith

Abstract

Positive associations between inflammatory biomarkers and risk of psychiatric disorders, including schizophrenia, have been reported in observational studies. However, conventional observational studies are prone to bias, such as reverse causation and residual confounding, thus limiting our understanding of the effect (if any) of inflammatory biomarkers on schizophrenia risk. To evaluate whether inflammatory biomarkers have an effect on the risk of developing schizophrenia. Two-sample mendelian randomization study using genetic variants associated with inflammatory biomarkers as instrumental variables to improve inference. Summary association results from large consortia of candidate gene or genome-wide association studies, including several epidemiologic studies with different designs, were used. Gene-inflammatory biomarker associations were estimated in pooled samples ranging from 1645 to more than 80 000 individuals, while gene-schizophrenia associations were estimated in more than 30 000 cases and more than 45 000 ancestry-matched controls. In most studies included in the consortia, participants were of European ancestry, and the prevalence of men was approximately 50%. All studies were conducted in adults, with a wide age ...Continue Reading

References

Apr 12, 2003·International Journal of Epidemiology·George Davey Smith, Shah Ebrahim
Jul 29, 2004·Schizophrenia Bulletin·Martin KnappJudit Simon
Mar 4, 2006·The American Journal of Psychiatry·William W EatonPreben Bo Mortensen
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Jan 20, 2009·Biological Psychiatry·Andrew H MillerCharles L Raison
May 1, 2008·Expert Review of Clinical Immunology·Andres PeisajovichTerry W Du Clos
Feb 18, 2011·BMJ : British Medical Journal·UNKNOWN C Reactive Protein Coronary Heart Disease Genetics Collaboration (CCGC)John Danesh
Feb 22, 2011·Pharmacology & Therapeutics·Lucile Capuron, Andrew H Miller
Dec 24, 2011·The American Journal of Psychiatry·Michael E BenrosPreben B Mortensen
Jan 10, 2012·The Journal of Clinical Psychiatry·Iris E SommerRené S Kahn
Mar 17, 2012·Lancet·UNKNOWN IL6R Genetics Consortium Emerging Risk Factors CollaborationJohn Danesh
Jun 19, 2012·Schizophrenia Research·Golam M KhandakerPeter B Jones
Dec 18, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Judith HogeHans-Willi Mittrücker
Feb 21, 2013·Translational Psychiatry·R M GardnerH Karlsson
Feb 23, 2013·Clinical Schizophrenia & Related Psychoses·Brian J MillerMark H Rapaport
Sep 3, 2013·Schizophrenia Bulletin·Marie Kim Wium-AndersenBørge Grønne Nordestgaard
Oct 12, 2013·Genetic Epidemiology·Stephen BurgessSimon G Thompson
Jul 25, 2014·Nature·UNKNOWN Schizophrenia Working Group of the Psychiatric Genomics Consortium
Aug 20, 2014·Nature Reviews. Rheumatology·Leonard H Calabrese, Stefan Rose-John
Mar 3, 2015·The Lancet. Diabetes & Endocrinology·UNKNOWN Interleukin 1 Genetics Consortium
May 8, 2015·Statistics in Medicine·Fabiola Del Greco MJohn R Thompson
Jun 8, 2015·International Journal of Epidemiology·Jack BowdenStephen Burgess
Sep 12, 2015·The Lancet. Psychiatry·Golam M KhandakerPeter B Jones
May 20, 2016·Scientific Reports·Masatoshi InoshitaTetsuro Ohmori
Jul 22, 2016·Human Molecular Genetics·R C RichmondC L Relton
Sep 8, 2016·Scientific Reports·Fernando Pires HartwigBernardo Lessa Horta
Mar 25, 2017·International Journal of Epidemiology·Fernando Pires HartwigGeorge Davey Smith

❮ Previous
Next ❯

Citations

Dec 27, 2017·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Melissa J GreenVaughan J Carr
Nov 2, 2018·Annals of Neurology·Rainer MalikUNKNOWN MEGASTROKE consortium and the International Stroke Genetics Consortium
Jan 24, 2019·JAMA Psychiatry·Karmel W ChoiUNKNOWN Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Nov 9, 2018·Sleep·Brian J MillerWilliam V McCall
Jun 27, 2019·American Journal of Public Health·Kathleen Ries Merikangas, Alison K Merikangas
Aug 23, 2019·Journal of Neurology·Huan CaiJialin Liang
Nov 2, 2019·Molecular Psychiatry·William R Reay, Murray J Cairns
Jan 3, 2020·Journal of Psychosocial Nursing and Mental Health Services·Barbara J Limandri
Jun 6, 2020·Frontiers in Psychiatry·Maria Salud García-GutiérrezJorge Manzanares
Jul 31, 2018·International Journal of Epidemiology·Linda KachuriRayjean J Hung
Jun 7, 2018·Nature Reviews. Genetics·Jean-Baptiste PingaultFrank Dudbridge
Oct 4, 2019·International Journal of Epidemiology·Symen Ligthart
May 6, 2019·JAMA Network Open·Renato PolimantiUNKNOWN Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group
May 18, 2018·Human Molecular Genetics·Gibran HemaniGeorge Davey Smith
Nov 30, 2018·Frontiers in Psychiatry·Jaana SuvisaariTuukka T Raij
Apr 11, 2018·Schizophrenia Bulletin·Benjamin Ian PerryGolam Khandaker
Feb 11, 2020·Frontiers in Psychiatry·Jing QiShao-Qing Ju
Jan 8, 2020·Frontiers in Psychiatry·Sara MomtazmaneshNima Rezaei
Nov 16, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M IoannouR A Schoevers
May 21, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·E J LiemburgH Knegtering
Nov 19, 2020·Clinical Nutrition Research·Hee Yun Cha, Soo Jin Yang
Mar 14, 2021·Neuroscience and Biobehavioral Reviews·Fabiana Corsi-Zuelli, Bill Deakin
Apr 17, 2021·Frontiers in Psychiatry·Ling-Yun ChenShao-Qing Ju
Jun 4, 2021·Frontiers in Psychiatry·Mohapradeep MohanSwaran Preet Singh
Jun 18, 2021·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Xiaoyu ZhuRan Li

❮ Previous
Next ❯

Software Mentioned

R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Aaron P ThriftPeter T Campbell
© 2022 Meta ULC. All rights reserved