Inflammatory Biomarkers and Risk of Atherosclerotic Cardiovascular Disease

Open Medicine
En YuLee-Ching Hwang

Abstract

Non-alcoholic fatty liver disease is an increasing health issue that associates with the development of atherosclerotic cardiovascular disease. This study correlates the association between fatty liver and inflammatory biomarkers with cardiovascular risk scores. This cross-sectional study enrolled 10,181 health examination participants from Northern Taiwan and administered a standardized questionnaire with important biochemical tests and abdominal sonography. To assess concentrations of inflammatory markers high sensitivity C-reactive protein (hs-CRP) and fibrinogen were used. Inflammatory marker levels were significantly increased with increasing fatty liver. In multivariate logistic regression analysis adjusted for major confounding factors, the odds ratios of elevated hs-CRP and fibrinogen were significantly higher in participants with mild or moderate-to-severe fatty liver compared to healthy individuals. The cardiovascular risk scores, above cut-off level 10%, were associated with higher levels of inflammatory biomarkers and fatty liver; odds ratio, 3.52 (2.60-4.77) for non-alcoholic fatty liver disease with hs-CRP, and 2.92 (2.12-4.00) for non-alcoholic fatty liver disease with fibrinogen. Inflammatory biomarkers (hs-CRP ...Continue Reading

References

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Citations

Dec 3, 2021·Nutrition and Cancer·Ana Luiza de Rezende Ferreira MendesIlana Nogueira Bezerra
Dec 11, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael H LeMindie H Nguyen

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

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