Inflammatory bowel disease: a systematic review on the value of diagnostic testing in primary care

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
P JellemaD A W M van der Windt

Abstract

The clinical presentation of inflammatory bowel disease in primary care represents a diagnostic challenge as its symptoms are heterogeneous and common. To assist the primary care physician, we have summarized the available evidence on diagnostic tests in patients with abdominal symptoms. We searched PubMed and Embase and screened references. Studies were selected if the design was a primary diagnostic study. Patients were adults attending with nonacute abdominal symptoms. Tests included clinical assessment, blood or faecal tests or abdominal ultrasonography. Quality assessment using a modified version of the QUADAS tool and data extraction was performed by two reviewers independently. Diagnostic two-by-two tables and pooled estimates of sensitivity and specificity are given. We refrained from pooling when there was considerable clinical or statistical heterogeneity. A total of 24 studies were included. While the diagnostic performance of the individual symptoms was highly variable (range sensitivity 0.0-0.96, specificity 0.09-1.0), the performance of symptom-based classification systems was both more consistent and better (sensitivity 0.65-1.0, specificity 0.17-0.82). Among faecal and blood tests, calprotectin was studied most ...Continue Reading

References

May 30, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·B ShineJ Landon
Mar 1, 1994·The British Journal of Surgery·N T BrewsterJ H Saunders
Oct 29, 2000·The American Journal of Gastroenterology·P J LimburgA R Zinsmeister
Aug 17, 2001·European Journal of Gastroenterology & Hepatology·M AstegianoM Rizzetto
Feb 6, 2004·Annals of Internal Medicine·Penny WhitingJos Kleijnen
May 1, 2004·Annals of Clinical Biochemistry·Julie WassellAnthony Hawthorne
May 26, 2004·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
May 29, 2004·Gastroenterology·Daniel W Hommes, Sander J H van Deventer
Aug 5, 2004·Inflammatory Bowel Diseases·Asher KornbluthBlair S Lewis
Sep 9, 2004·Alimentary Pharmacology & Therapeutics·J Eaden
Sep 9, 2004·Alimentary Pharmacology & Therapeutics·S DolwaniA B Hawthorne
Oct 12, 2004·Inflammatory Bowel Diseases·Fabrizio ParenteGabriele Bianchi Porro
Jan 29, 2005·Inflammatory Bowel Diseases·Nadia PallottaEnrico Corazziari
Feb 18, 2005·European Journal of Gastroenterology & Hepatology·Fabrizio ParenteGabriele Bianchi Porro
Feb 22, 2005·The British Journal of Ophthalmology·M A R SiddiquiJ Burr
Mar 17, 2005·Radiology·Nynke SmidtHenrica C W de Vet
Jul 1, 2005·Radiology·Mirella FraquelliDario Conte
Jul 2, 2005·Journal of Pediatric Gastroenterology and Nutrition·UNKNOWN IBD Working Group of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition
Sep 20, 2005·Journal of Clinical Epidemiology·Johannes B ReitsmaAeilko H Zwinderman
Sep 29, 2005·Endoscopy·A KornbluthUNKNOWN ICCE
Dec 13, 2005·Clinical Chemistry·Xavier Bossuyt
Feb 17, 2006·Gut·E F StangeUNKNOWN European Crohn's and Colitis Organisation
Jun 16, 2006·Inflammatory Bowel Diseases·Michael R Konikoff, Lee A Denson
Jun 29, 2006·Alimentary Pharmacology & Therapeutics·W E WhiteheadD A Drossman
Jul 14, 2006·BMC Medical Research Methodology·Javier ZamoraArri Coomarasamy
Jul 14, 2006·International Journal of Colorectal Disease·Renata D'IncàGiacomo Carlo Sturniolo
Jul 25, 2006·AJR. American Journal of Roentgenology·Constantine Gatsonis, Prashni Paliwal
Jul 20, 2007·Inflammatory Bowel Diseases·Laurent Peyrin-BirouletMathias Chamaillard
Oct 22, 2008·Scandinavian Journal of Gastroenterology·Anders LassonPer-Ove Stotzer
Apr 10, 2009·Internal and Emergency Medicine·Gianni VirgiliRoberto Gusinu
Oct 9, 2013·Systematic Reviews·Mariska M G LeeflangPetra Macaskill

❮ Previous
Next ❯

Citations

Jun 17, 2014·Journal of Crohn's & Colitis·Vincenzo VillanacciGabrio Bassotti
Feb 24, 2016·Primary Health Care Research & Development·James TurvillAlex Ford
Jan 13, 2015·Frontline Gastroenterology·A DhaliwalR P Arasaradnam
Nov 28, 2013·BMC Family Practice·Gea A HoltmanMarjolein Y Berger
Oct 17, 2018·Journal of Evaluation in Clinical Practice·Corinne ChmielOliver Senn
Mar 29, 2018·Frontline Gastroenterology·Matthew J BrookesAntony Barney Hawthorne
Sep 25, 2018·Frontline Gastroenterology·James TurvillStacey Marriott
Sep 21, 2011·Annals of Clinical Biochemistry·Julie WassellElla Brewer
Dec 19, 2015·Pediatrics·Gea A HoltmanMarjolein Y Berger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.