Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments

Mediators of Inflammation
Bruno Rafael Ramos de MattosPatricia Ucelli Simioni

Abstract

Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the intestinal tract associated with an imbalance of the intestinal microbiota. Crohn's disease (CD) and ulcerative colitis (UC) are the most widely known types of IBD and have been the focus of attention due to their increasing incidence. Recent studies have pointed out genes associated with IBD susceptibility that, together with environment factors, may contribute to the outcome of the disease. In ulcerative colitis, there are several therapies available, depending on the stage of the disease. Aminosalicylates, corticosteroids, and cyclosporine are used to treat mild, moderate, and severe disease, respectively. In Crohn's disease, drug choices are dependent on both location and behavior of the disease. Nowadays, advances in treatments for IBD have included biological therapies, based mainly on monoclonal antibodies or fusion proteins, such as anti-TNF drugs. Notwithstanding the high cost involved, these biological therapies show a high index of remission, enabling a significant reduction in cases of surgery and hospitalization. Furthermore, migration inhibitors and new cytokine blockers are also a promising alternative for treating patients with IB...Continue Reading

References

Jun 1, 1996·The Journal of Experimental Medicine·M F NeurathW Strober
May 5, 1998·Clinical and Experimental Immunology·C RoozendaalC G Kallenberg
May 6, 1999·The New England Journal of Medicine·D H PresentS J van Deventer
Mar 16, 2001·Expert Opinion on Pharmacotherapy·L Y Kam, S R Targan
Jun 1, 2001·Inflammatory Bowel Diseases·B E SandsD K Podolsky
Jun 4, 2002·Nature Medicine·Markus F NeurathLaurie H Glimcher
Jul 19, 2002·Gastroenterology Clinics of North America·Scott Plevy
Dec 24, 2002·The British Journal of Nutrition·Philip C Calder, Samantha Kew
Jun 14, 2003·Gastroenterology·Thomas R ZieglerLorraine M Leader
Jun 8, 2004·Immunologic Research·Ifor R Williams
Aug 13, 2004·Gut·M J CarterUNKNOWN IBD Section, British Society of Gastroenterology
Sep 14, 2004·Gastroenterology·Sandro ArdizzoneGabriele Bianchi Porro
Jun 17, 2005·The New England Journal of Medicine·Brian G FeaganMargaret K Vandervoort
Jun 21, 2005·Immunity·Lars Eckmann, Michael Karin
Jul 29, 2005·Immunological Reviews·Ana M C Faria, Howard L Weiner
Nov 4, 2005·Drugs·Sandro Ardizzone, Gabriele Bianchi Porro
Jan 31, 2006·Alimentary Pharmacology & Therapeutics·P RutgeertsS Vermeire
Feb 14, 2006·Gastroenterology·Eamonn M M Quigley, Rodrigo Quera
Jun 27, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Paul RutgeertsUNKNOWN Onercept Study Group
Oct 13, 2006·Clinical and Experimental Immunology·R ItoO Mazda
Oct 14, 2006·Paediatric Drugs·Paul A Rufo, Athos Bousvaros
Oct 24, 2006·Annals of the New York Academy of Sciences·Jean-Pierre Hugot
Dec 13, 2006·Clinical & Developmental Immunology·Ana M C Faria, Howard L Weiner
May 23, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Stephanie K A Blick, Monique P Curran
Jun 29, 2007·European Journal of Clinical Pharmacology·Andrea CassinottiGabriele Bianchi Porro
Sep 5, 2007·Alimentary Pharmacology & Therapeutics·G Bianchi PorroS Ardizzone
Apr 9, 2008·World Journal of Gastroenterology : WJG·M-I Torres, A Rios
May 27, 2008·Nature Reviews. Immunology·Judy H Cho
Jun 14, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Laurent Peyrin-BirouletJean-Frédéric Colombel
Aug 19, 2008·Gastroenterology·William J SandbornUNKNOWN Ustekinumab Crohn's Disease Study Group
Dec 23, 2008·Mucosal Immunology·G MonteleoneT T MacDonald
Mar 3, 2009·Gastroenterology·Paul RutgeertsGert Van Assche
May 27, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Arturo BorzutzkyFatma Dedeoglu
Jun 3, 2009·Expert Review of Gastroenterology & Hepatology·Laura Yun, Stephen Hanauer
Aug 13, 2009·World Journal of Gastroenterology : WJG·Manuel Barreiro-de AcostaJuan Enrique Dominguez-Muñoz
Oct 16, 2009·European Journal of Gastroenterology & Hepatology·Brita Ardesjö LundgrenOlov Ekwall

❮ Previous
Next ❯

Citations

Sep 1, 2015·International Immunopharmacology·Ashok Kumar PanduranganZeinab Saadatdoust
Jun 4, 2016·Pharmacological Reports : PR·Jan BilskiTomasz Brzozowski
Jan 30, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mary B LeonardClinton T Rubin
Jul 15, 2016·Cancer Biology & Therapy·Francesco De FrancescoUmberto Cillo
Dec 21, 2016·International Journal of Biological Macromolecules·Ram Sarup SinghJohn F Kennedy
Jul 8, 2017·Pharmacogenomics·Sara RufiniPaola Borgiani
Jun 9, 2017·Expert Opinion on Biological Therapy·Priyanka Vashisht, James O'dell
Apr 5, 2017·Inflammatory Bowel Diseases·Ashwin N AnanthakrishnanVijay Yajnik
Aug 16, 2016·British Journal of Nursing : BJN·Jane Fletcher
Jun 23, 2018·Molecular Nutrition & Food Research·Fernanda G D E SilvaWirla M S C Tamashiro
Aug 12, 2018·Immunology·Pablo Palazon-Riquelme, Gloria Lopez-Castejon
Dec 12, 2018·Applied and Environmental Microbiology·Lucas J Kirschman, Kathryn C Milligan-Myhre
May 31, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Rajendra SangarajuRamakrishna Sistla
Feb 11, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hongjian ZhouChao Ke
Mar 10, 2020·Expert Opinion on Emerging Drugs·Nicola PuglieseSilvio Danese
Dec 21, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mel Pilar EspaillatLina M Obeid
Aug 10, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L M WardD R Mack
Mar 22, 2019·Molecular Medicine Reports·Yu Qi QiaoZhi Hua Ran
Nov 30, 2016·World Journal of Gastroenterology : WJG·Ya-Hui MaXin-Juan Liu
Sep 12, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephen J KeelyNatalia K Lajczak-McGinley
Sep 10, 2020·Frontiers in Immunology·Jefferson Elias-OliveiraDaniela Carlos
Aug 2, 2018·Clinical Science·Simona RonchettiCarlo Riccardi
Jun 27, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sumeet SolankiYatrik M Shah
Sep 17, 2019·International Journal of Molecular Medicine·Yan SunLegao Chen
Oct 11, 2019·Therapeutic Advances in Gastroenterology·María ChaparroJavier P Gisbert
Jun 28, 2017·World Journal of Gastroenterology : WJG·Malgorzata MatusiewiczMalgorzata Krzystek-Korpacka
Jan 28, 2021·Pharmacogenomics and Personalized Medicine·Lingying DaiHaihua Qian

❮ Previous
Next ❯

Methods Mentioned

BETA
phage display
glycosylation

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Inflammatory Bowel Diseases
Amnon Sonnenberg
Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
H Sales-CamposC R B Cardoso
© 2021 Meta ULC. All rights reserved