PMID: 9166024Apr 1, 1997Paper

Inflammatory bowel disease and predisposition to osteopenia

Archives of Disease in Childhood
F J CowanH R Jenkins

Abstract

The prevalence of osteopenia in children with inflammatory bowel disease (IBD) is unknown. The effect of nutritional state, disease activity, and steroid therapy on bone mineral content (BMC) of whole body, lumbar spine, and left femoral neck measured by dual energy x ray absorptiometry in 32 children with IBD was assessed by comparison with 58 healthy local school children. Using the control data, a predicted BMC was calculated taking into account bone area, age, height, weight, and pubertal stage. The measured BMC in children with IBD was expressed as a percentage of this predicted value (% BMC). Mean (SD) % BMC was significantly reduced for the whole body and left femoral neck in the children with IBD (97.0 (4.5)% and 93.1 (12.0)% respectively, p < 0.05). Of the children with IBD, 41% had a % BMC less than 1 SD below the mean for the whole body and 47% at the femoral neck. Reduction in % BMC was associated with steroid usage but not with the magnitude of steroid dose, disease activity, or biochemical markers of bone metabolism. In conclusion, osteopenia is relatively common in childhood IBD and may be partly related to the previous use of steroids.

References

Dec 1, 1992·Scandinavian Journal of Gastroenterology·D ClementsJ E Compston
Nov 11, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C W SlemendaC C Johnston
Apr 1, 1971·Archives of Disease in Childhood·C G Brook
Aug 1, 1967·The British Journal of Nutrition·J V Durnin, M M Rahaman
Mar 8, 1980·Lancet·R F Harvey, J M Bradshaw
Sep 1, 1995·Archives of Disease in Childhood·F J CowanH R Jenkins
Jun 1, 1995·Archives of Disease in Childhood·A M BootS M de Muinck Keizer-Schrama
Jul 1, 1995·Archives of Disease in Childhood·J V FreemanM A Preece
Jul 1, 1995·Archives of Disease in Childhood·T J ColeM A Preece
Feb 1, 1995·Archives of Disease in Childhood·N J Shaw, N J Bishop
Feb 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C N BernsteinF Shanahan
Feb 1, 1995·Gastroenterology·V AbitbolB Amor
Feb 1, 1994·Journal of Pediatric Gastroenterology and Nutrition·H HildebrandB Kristiansson
Sep 1, 1994·The Journal of Allergy and Clinical Immunology·K A KinbergJ C Gallagher
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·L C MartinatiA L Boner

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Citations

Jan 9, 2007·Inflammatory Bowel Diseases·Massimiliano PaganelliSalvatore Cucchiara
Jan 1, 2008·Reviews in Endocrine & Metabolic Disorders·Anuradha Viswanathan, Francisco A Sylvester
May 8, 2003·Current Gastroenterology Reports·Manisha Harpavat, David J Keljo
Jun 7, 2005·The Journal of Nutritional Biochemistry·Stacey L CohenWendy E Ward
Sep 16, 2011·The British Journal of Nutrition·Joanne F OliemanDick Tibboel
May 7, 2004·Journal of Clinical Gastroenterology·Manisha HarpavatMiguel D Regueiro
Mar 6, 1999·Journal of Pediatric Gastroenterology and Nutrition·A K AkobengA G Thomas
Jul 23, 2004·Journal of Pediatric Gastroenterology and Nutrition·Stefano Mora, Graziano Barera
Nov 11, 1999·Current Opinion in Pediatrics·F A Sylvester
Jun 20, 2002·European Journal of Gastroenterology & Hepatology·Juliet E Compston
Aug 24, 1999·Inflammatory Bowel Diseases·E J SemeaoV A Stallings
Mar 8, 2005·Journal of Pediatric Gastroenterology and Nutrition·Manisha HarpavatDavid J Keljo
Mar 30, 2005·Journal of Pediatric Gastroenterology and Nutrition·Lori J StarkJames Heubi
Jul 5, 2006·Journal of Pediatric Gastroenterology and Nutrition·Frank WaltherAnnette Findeisen
Jun 23, 2011·Journal of Pediatric Gastroenterology and Nutrition·Helen PappaCatherine Gordon
Jul 26, 2002·Archives of Disease in Childhood·T Mushtaq, S F Ahmed
May 4, 2012·BMC Gastroenterology·Mostafa Abdel-Aziz El-HodhodAlhag Ahmed Mohamed Ramadan
Nov 3, 2006·Pediatrics·Helen M PappaRichard J Grand
Aug 11, 2000·Paediatric Drugs·R M Beattie
Mar 21, 2008·Digestive Diseases and Sciences·Letícia Helena Caldas LopesUlysses Fagundes-Neto
Dec 4, 2009·Journal of Gastroenterology·Kylie E WhittenAndrew S Day
Jan 9, 2009·Digestive Diseases and Sciences·Heidi C WatersBijan Nejadnik
Aug 27, 2010·Gastroentérologie Clinique Et Biologique·F SamsonA Dabadie
Jul 1, 2008·The Journal of Pediatrics·Melvin B HeymanSelna Kaplan
Mar 11, 2008·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·D DelalandeI Koné-Paut
Nov 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jon M BurnhamMary B Leonard
Jul 6, 2004·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·O BourgesJ P Cézard
Nov 5, 1999·The Journal of Pediatrics·E J SemeaoV A Stallings
Jul 19, 2002·Gastroenterology Clinics of North America·Toby O Graham, Hossam M Kandil
Mar 22, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Anthony E WiskinRobert M Beattie
May 21, 2005·Inflammatory Bowel Diseases·Elizabeth HaitRichard Grand
Nov 30, 2006·Journal of Pediatric Gastroenterology and Nutrition·Rabindranath PersadRobert M Issenman
Jun 27, 2002·Expert Opinion on Pharmacotherapy·A Ronald F Bremner, R Mark Beattie
Jan 19, 2010·Journal of Pediatric Gastroenterology and Nutrition·Bhupinder K SandhuUNKNOWN IBD Working Group of the British Society of Paediatric Gastroenterology, Hepatology, and Nutrition
Jan 19, 2010·Journal of Pediatric Gastroenterology and Nutrition·D C WilsonS H Murch

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