Inflammatory bowel disease evaluated by low-field magnetic resonance imaging. Comparison with endoscopy, 99mTc-HMPAO leucocyte scintigraphy, conventional radiography and surgery

Scandinavian Journal of Gastroenterology
S M MadsenP Schlichting

Abstract

To evaluate the use of low-field magnetic resonance imaging (MRI) in active inflammatory bowel disease (IBD). MRI was executed in a consecutive cohort of 28 patients with Crohn disease (CD) and in 17 with ulcerative colitis (UC) prior to glucocorticoid treatment (1 mg prednisolone orally/kg body weight/day). MRI was repeated after 2-3 weeks (22 CD, 12 UC), and again after treatment completion or prior to surgery (18 CD, 6 UC). Five bowel segments were evaluated separately. MRIs were blindly evaluated by two observers, and findings compared with 39 leucocyte scintigraphies, 38 endoscopies, 15 double-contrast barium enemas, 66 small-bowel radiographic examinations and surgery in 23 patients. In CD, blinded evaluation revealed a kappa (kappa) of 0.84 (95% confidence interval (CI) 0.78-0.91). In UC, kappa was 0.66 (95% CI 0.55-0.78). Agreements regarding disease extension between MRI and other modalities in CD were found in 345 bowel segments out of 391 (88.2%) at risk, and in UC in 209/235 (88.9%). Colonic disease activity gradings by radiography and endoscopy correlated significantly with T2-signal intensity (SI(T2)) and increments in T1-signal intensity (%SI(T1)) in both diseases. Significant correlations between MRI indices of ...Continue Reading

Citations

Apr 13, 2006·Gut·B A Mackalski, C N Bernstein
Jun 13, 2009·World Journal of Gastroenterology : WJG·Maria I StathakiIoannis E Koutroubakis
May 24, 2005·AJR. American Journal of Roentgenology·G A Javier SempereElisa Orti
Jul 18, 2006·Pediatric Radiology·A Ronald BremnerR Mark Beattie
Feb 3, 2007·Alimentary Pharmacology & Therapeutics·V SubramanianR C G Pollok
Feb 1, 2006·Abdominal Imaging·A G SchreyerH Herfarth
Oct 6, 2007·Scandinavian Journal of Gastroenterology·Dietmar J DinterUlrich Böcker
Mar 9, 2011·Journal of Medical Imaging and Radiation Oncology·Arian LasockiStephen Farish

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