Inflammatory bowel disease is associated with a novel promoter polymorphism of natural resistance-associated macrophage protein 1 (NRAMP1) gene

Tissue Antigens
Y KojimaT Shimosegawa

Abstract

Inflammatory bowel diseases (IBD) representing both Crohn's disease and ulcerative colitis are characterized by chronic activation of macrophages. Natural resistance-associated macrophage protein 1 (NRAMP1) gene regulates macrophage activation of antimicrobial activity and has many pleiotropic effects on macrophage functions. To explore the role of the NRAMP1 gene in IBD susceptibility, we examined the promoter sequence of the NRAMP1 gene whose polymorphisms have been reported to influence the transcriptional activity of the NRAMP1 gene. One novel allele (allele 7) and two previously reported alleles (alleles 2 and 3) have been determined in a Japanese population. We investigated the association of IBD with these three alleles. The allele frequency of allele 7 was significantly higher in patients with Crohn's disease (11.1%) and ulcerative colitis (11.2%) than those in the healthy control group (4.5%) (Pc=0.015, Pc=0.018, respectively). Therefore, our findings suggest that the novel promoter polymorphism of the NRAMP1 gene may influence susceptibility to IBD in the Japanese population.

References

Jul 17, 1993·Lancet·B DerkxS van Deventer
Jan 7, 1998·The Journal of Infectious Diseases·L AbelE Schurr
Mar 7, 2000·Tissue Antigens·D P SingalG Zhang
Apr 12, 2000·Microbes and Infection·J M BlackwellE N Miller
Jun 17, 2000·Arthritis and Rheumatism·C B SanjeeviJ M Blackwell

❮ Previous
Next ❯

Citations

May 6, 2008·Inflammatory Bowel Diseases·Maria GazouliNicholas P Anagnou
Nov 29, 2012·Molecular Biology Reports·Styliani TakaNicholas P Anagnou
Apr 29, 2011·BMC Medical Genetics·Jennie H M YangJohn A Todd
Mar 11, 2005·BMC Medical Genetics·Nigel P S CrawfordSusan Galandiuk
Nov 1, 2008·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Maria GazouliDimitrios Vassilopoulos
Mar 27, 2007·Digestive Diseases and Sciences·Irit ChermeshBen Zion Levi
Jul 27, 2007·DNA Sequence : the Journal of DNA Sequencing and Mapping·Zhen-Fang WuXi-Quan Zhang
Jun 23, 2004·Trends in Immunology·Joost J SmitFrans P Nijkamp
May 19, 2004·Trends in Parasitology·Jenefer M BlackwellMuntaser E Ibrahim
Jan 28, 2016·Memórias do Instituto Oswaldo Cruz·Maria José Franco BrochadoAna Maria Roselino
Jan 11, 2013·Memórias do Instituto Oswaldo Cruz·Vinicius FavaErwin Schurr
Mar 7, 2018·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Taher AzimiHossein Dabiri
Jul 12, 2002·The Journal of Biological Chemistry·Holly BowenC Howard Barton
Dec 18, 2002·Genes and Immunity·J FitnessA V S Hill
Sep 23, 2003·Current Opinion in Allergy and Clinical Immunology·Graham A W RookLaura Rosa Brunet

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.