Inflammatory bowel disease pathobiology: the role of the interferon signature

Annals of Gastroenterology : Quarterly Publication of the Hellenic Society of Gastroenterology
Nicolaos-Panagiotis AndreouMaria Gazouli

Abstract

The pathogenesis of inflammatory bowel disease (IBD) is still unclear, but includes both inflammatory and autoimmune reactions. Current methodological approaches could better elucidate the cytokine pathways and the genetics involved in the etiopathogenesis of this disease. Interferons (IFNs) are cytokines that play a key role in autoimmune/inflammatory disorders because of their pro- and anti-inflammatory properties as well as their immunoregulatory functions. An increased expression of IFN-regulated genes, widely known as an IFN signature, has been reported in blood and tissue from patients with autoimmune disorders. In this review, we present the function as well as the clinical and therapeutic potential of the IFN signature. Current data demonstrate that the IFN signature can be used as a biomarker that defines disease activity in autoimmune diseases, although this has not been thoroughly studied in IBD. Consequently, further investigation of the IFN signature in IBD would be essential for a better understanding of its actions.

Citations

Apr 26, 2020·International Journal of Molecular Sciences·Antonelly Cassio Alves de CarvalhoSandra M Barbalho
Jul 9, 2020·International Journal of Molecular Sciences·Noha Ahmed Nasef, Sunali Mehta
Nov 13, 2020·Frontiers in Immunology·Vanessa Figliuolo da PazPawel R Kiela
Jun 8, 2021·Expert Review of Clinical Immunology·Vassilis E PapadopoulosClio P Mavragani
Jun 19, 2021·Frontiers in Medicine·Iris StolzerClaudia Günther
Dec 29, 2020·Journal of Medicinal Chemistry·Chunjian LiuDavid S Weinstein
Aug 13, 2021·Frontiers in Cell and Developmental Biology·Lili YeChunhui Cui

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