Inflammatory bowel disease serologies in ankylosing spondylitis patients: a pilot study.

Arthritis Research & Therapy
Matthew L MundwilerMichael Weisman

Abstract

Ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) share similarities and are classified as spondyloarthropathies. In IBD, anti-Saccharomyces cerevisiae antibody (ASCA), anti-I2 (associated with anti-Pseudomonas activity), anti-Escherichia coli outer membrane porin C (anti-OmpC), anti-flagellin (anti-CBir1), and antineutrophil cytoplasmic antibodies (ANCA) possess clinical significance. Because of the overlap between the two conditions, a pilot study was designed to compare the frequency of these antibodies in AS patients compared to normal controls. Serum stored from 80 AS patients and 80 control subjects was available for analysis. ASCA, anti-I2, anti-OmpC, anti-CBir1, and ANCA studies were completed on all serum samples using Enzyme-Linked Immunosorbent Assay (ELISA) methodology. The following analyses were performed: comparison of positivity based on the established values in IBD, median values, the number of subjects in each serology in the 4th quartile of a normal distribution, and the mean quartile sum of all the antibodies. There was no difference in positivity rates between AS and control groups with the established IBD values. The median anti-I2 response was significantly higher in AS than in controls (1...Continue Reading

References

Nov 28, 2006·Annals of the Rheumatic Diseases·Wonuk LeeMichael H Weisman
Jan 30, 2007·Inflammatory Bowel Diseases·Konstantinos A PapadakisStephan R Targan
Jan 1, 2008·Arthritis and Rheumatism·Charles G HelmickUNKNOWN National Arthritis Data Workgroup
Apr 3, 2008·Arthritis and Rheumatism·Proton RahmanWalter P Maksymowych

❮ Previous
Next ❯

Citations

Jun 13, 2013·Zeitschrift für Rheumatologie·G VarkasD Elewaut
Dec 11, 2013·Nature Reviews. Rheumatology·Peggy Jacques, Dirk Elewaut
Dec 1, 2012·Arthritis Research & Therapy·Franziska G MatzkiesMichael H Weisman
Jan 5, 2014·PLoS Pathogens·Lihui LiuHongmin Li
Dec 2, 2014·Rheumatic Diseases Clinics of North America·Dinny Wallis, Robert D Inman
Feb 7, 2016·Autoimmunity Reviews·Klára PrajzlerováMária Filková
Jan 1, 2016·Rheumatology International·Jayakanthan KabeerdossDebashish Danda
May 15, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Matthew L Stoll
Mar 20, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Jérémy MailletPhilippe Dieudé
Sep 13, 2015·Best Practice & Research. Clinical Rheumatology·Mary-Ellen CostelloMatthew A Brown
May 7, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Daniel Wendling
Jan 13, 2015·Joint, Bone, Spine : Revue Du Rhumatisme·Daniel WendlingClément Prati
Jun 12, 2016·Autoimmunity Reviews·Dana H F QuadenVeerle Somers
Feb 17, 2018·The Journal of Rheumatology·Uri KopylovErnest G Seidman
Apr 18, 2012·Nature Reviews. Rheumatology·Liesbet Van PraetDirk Elewaut
Jul 6, 2019·Journal of Immunology Research·Devis BenfaremoArmando Gabrielli
Apr 21, 2018·Frontiers in Medicine·Martin LaurenceJames T Rosenbaum
Feb 7, 2019·Frontiers in Immunology·Yuan LiuGuixiu Shi

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
enzyme-linked immunosorbent assay

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.