Inflammatory bowel disease: the role of inflammatory cytokine gene polymorphisms

Mediators of Inflammation
Joanna BaldingOwen P Smith

Abstract

The mechanisms responsible for development of inflammatory bowel disease (IBD) have not been fully elucidated, although the main cause of disease pathology is attributed to up-regulated inflammatory processes. The aim of this study was to investigate frequencies of polymorphisms in genes encoding pro-inflammatory and anti-inflammatory markers in IBD patients and controls. We determined genotypes of patients with IBD (n= 172) and healthy controls (n= 389) for polymorphisms in genes encoding various cytokines (interleukin (IL)-1beta, IL-6, tumour necrosis factor (TNF), IL-10, IL-1 receptor antagonist). Association of these genotypes to disease incidence and pathophysiology was investigated. No strong association was found with occurrence of IBD. Variation was observed between the ulcerative colitis study group and the control population for the TNF-alpha-308 polymorphism (p= 0.0135). There was also variation in the frequency of IL-6-174 and TNF-alpha-308 genotypes in the ulcerative colitis group compared with the Crohn's disease group (p= 0.01). We concluded that polymorphisms in inflammatory genes are associated with variations in IBD phenotype and disease susceptibility. Whether the polymorphisms are directly involved in regula...Continue Reading

References

Jul 1, 1995·Scandinavian Journal of Gastroenterology·P MunkholmV Binder
Dec 1, 1996·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·C E WhichelowJ A Sachs
Feb 1, 1997·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·D M TurnerI V Hutchinson
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·A G WilsonG W Duff
Mar 31, 1998·Scandinavian Journal of Immunology·S SanttilaM Hurme
Jul 15, 1998·Alimentary Pharmacology & Therapeutics·R C EvansJ M Rhodes
Aug 18, 1999·JAMA : the Journal of the American Medical Association·J P MiraJ F Dhainaut
Nov 7, 1999·Tissue Antigens·A TagoreI V Hutchinson
Feb 24, 2001·European Journal of Gastroenterology & Hepatology·W KleinJ T Epplen
Oct 6, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J W FijenJ G Zijlstra
Jan 26, 2002·Lancet·Fergus Shanahan
Aug 20, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Markus NauckWinfried März

❮ Previous
Next ❯

Citations

Jan 11, 2005·The Journal of Burn Care & Rehabilitation·Ankush Gosain, Richard L Gamelli
Oct 1, 2013·BMC Research Notes·Neogelia Pereira AlmeidaAndré Castro Lyra
Aug 14, 2008·World Journal of Gastroenterology : WJG·Lynnette R FergusonDug Yeo Han
Apr 4, 2014·World Journal of Gastroenterology : WJG·Lili MagyariBela Melegh
Apr 8, 2014·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Mortaza BonyadiManoochehr Khoshbaten
Apr 28, 2006·Scandinavian Journal of Gastroenterology·Yasemin CelikA Mithat Bozdayi
Sep 1, 2015·Journal of Digestive Diseases·Biljana StankovicSonja Pavlovic
Sep 21, 2011·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Shu-Chen WeiJau-Min Wong
Aug 1, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Vito D CorletoGianfranco Delle Fave
Sep 1, 2005·Journal of Clinical Periodontology·Bruno G LoosMarja L Laine
Jun 8, 2012·International Journal of Cancer. Journal International Du Cancer·Kristina L BondurantMartha L Slattery
Jun 4, 2010·International Journal of Immunogenetics·E Garza-GonzálezF J Bosques-Padilla
May 12, 2010·Alimentary Pharmacology & Therapeutics·Z HanD Fan
Aug 26, 2006·Cytokine·Suk-Kyun YangKyuyoung Song
Oct 6, 2016·Expert Review of Clinical Immunology·Maureen C TurinaDominique Baeten
May 19, 2006·Expert Review of Molecular Diagnostics·Farid E Ahmed
Jun 25, 2009·The American Journal of Gastroenterology·Catarina Sousa GuerreiroMarília Cravo
Apr 30, 2011·European Journal of Gastroenterology & Hepatology·Ritva M KoskelaRiitta A Karttunen
Feb 22, 2008·The American Journal of Gastroenterology·Megan M Garrity-ParkThomas C Smyrk
Mar 13, 2008·European Journal of Gastroenterology & Hepatology·Ritva M KoskelaRiitta A Karttunen
Nov 26, 2009·Journal of Pediatric Gastroenterology and Nutrition·Keren Sagiv-FriedgutEsther Leshinsky-Silver
Sep 26, 2017·Annals of the New York Academy of Sciences·Yaning ShiMing Miao
Sep 6, 2017·Immunological Investigations·Nasser Ebrahimi DaryaniNima Rezaei
Dec 14, 2018·Frontiers in Immunology·Gareth-Rhys JonesAndrew S MacDonald
Jun 20, 2021·Clinical and Translational Science·Debora CurciGabriele Stocco

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here