Inflammatory bowel disease therapy: blockade of cytokines and cytokine signaling pathways

Current Opinion in Gastroenterology
Jesus K Yamamoto-Furusho

Abstract

Treatment of inflammatory bowel disease (IBD) patients can vary depending on the degree of response, lack of response or intolerance to conventional or biological agents aimed at blocking various cytokines or integrins. Recent therapies targeting several cytokines were reviewed to evaluate efficacy in IBD patients. Ustekinumab is an interleukin inhibitor which blocks the p40 subunit of IL-12 and IL-23 axis and is already approved for the treatment of Crohn's disease patients, specially those who had inadequate response or intolerance to conventional treatment with anti-TNF-α agents. Several treatments have been developed that are focused on the blockade of specific cytokines such as IL-6, IL-12, IL-13, IL-17, IL-23 and a chemokine named IFN-γ-inducible protein-10 as well as some oral small-molecule inhibitors of intracellular cytoplasmic tyrosine kinases like tofacitinib, filgotinib and upadacitinib. Several biologics blocking different and specific cytokines and oral small molecule agents have been and are being evaluated in IBD patients. A comprehensive understanding of the underlying immunological mechanisms will allow to develop effective and safe agents that inhibit one or more cytokines to improve the outcome in patients ...Continue Reading

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Citations

Sep 7, 2018·Current Opinion in Gastroenterology·Kenneth D SwansonEfi Kokkotou
Oct 3, 2019·Current Opinion in Gastroenterology·George Mantese
Oct 22, 2019·Arquivos De Gastroenterologia·Abel Botelho QuaresmaPaulo Gustavo Kotze
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Aug 20, 2021·Frontiers in Medicine·Michael StürzlElisabeth Naschberger

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Methods Mentioned

BETA
biopsies
biopsy

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