Inflammatory breast cancer: novel preoperative therapies

Clinical Breast Cancer
Beth A Overmoyer

Abstract

The treatment of inflammatory breast cancer (IBC) has been hampered by the diagnostic rarity of the disease and its consequent inclusion in clinical trials of preoperative treatment for the more indolent locally advanced breast cancer (LABC). Patients with IBC have a 2-fold greater probability of dying of their disease compared with patients diagnosed with LABC. The aggressive clinical portrait of IBC supports the recent investigative focus on determining molecular changes specific to IBC and developing novel systemic therapies that will favorably affect its poor disease prognosis. A significant amount of laboratory research has been involved in defining a specific "inflammatory signature" for IBC, denoting molecular changes consistently found in IBC. This work has involved human IBC tissue and cell lines and has demonstrated overexpression of several molecules governing metastatic dissemination, such as overexpression of E-cadherin concurrent with a dysfunctional mucin 1. An increased prevalence of mutant TP53, overexpression of RhoC, and vascular endothelial growth factor-A has been found to contribute to the dominant influence of angiogenesis in this disease. A greater understanding of the molecular mechanisms governing the ...Continue Reading

References

Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·U M MollA J Levine
Aug 9, 1995·International Journal of Cancer. Journal International Du Cancer·P BonnierL Piana
Mar 21, 2002·Journal of the National Cancer Institute·Rakesh K Jain, Brenda T Fenton
Aug 29, 2002·Cancer Biology & Therapy·Kornelia Polyak
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harold J BursteinEric P Winer
Jun 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William F AndersonShine Chang
Jan 22, 2004·International Journal of Cancer. Journal International Du Cancer·Guenther GruberRichard H Greiner
Mar 3, 2004·The Journal of Pathology·Emmanuelle Charafe-JauffretPatrice Viens
May 14, 2004·Neoplasia : an International Journal for Oncology Research·Celina G KleerSofia D Merajver
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ilse Van der AuweraLuc Y Dirix
Mar 23, 2005·Cancer Research·François BertucciDaniel Birnbaum
Apr 6, 2005·The Journal of Experimental Medicine·Satoshi HirakawaMichael Detmar
Jan 5, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Suparna Bonthala WedamSandra M Swain
Feb 10, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Holly K DressmanKimberly Blackwell
Mar 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Judith HurleyDennis J Slamon
Mar 28, 2006·Future Oncology·Charles H Yang, Massimo Cristofanilli
Jun 7, 2006·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Masataka SawakiKiyohiko Hatake
Sep 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dang M NguyenJenny C Chang
Feb 24, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lyndsay N HarrisEric P Winer
Jul 6, 2007·The New England Journal of Medicine·Clifford A Hudis
Sep 4, 2007·The Oncologist·Ana M Gonzalez-AnguloGabriel N Hortobágyi
Oct 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Beth OvermoyerScot C Remick
Jan 24, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen JohnstonNeil L Spector
Feb 6, 2008·BMC Cancer·Florence LereboursIvan Bieche
Feb 9, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen ChiaDavid A Mankoff
Feb 27, 2008·Cancer·Shaheenah DawoodUNKNOWN Inflammatory Breast Cancer Research Group
Jul 5, 2008·The American Journal of Pathology·Yi XiaoSanford H Barsky
Aug 20, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R S MehtaK Kong
Nov 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven Van LaereLuc Dirix
May 7, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joseph BaarBeth Overmoyer

❮ Previous
Next ❯

Citations

Nov 15, 2013·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Eren D YehAnnick D Van den Abbeele
Mar 24, 2012·Biochimica Et Biophysica Acta·Fausto J RodriguezPanos Z Anastasiadis
Feb 22, 2011·Journal of Surgical Oncology·Issam Makhoul, Elias Kiwan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.