Inflammatory Breast Cancer: Patterns of Failure and the Case for Aggressive Locoregional Management

Annals of Surgical Oncology
Laura E G WarrenJennifer R Bellon

Abstract

Inflammatory breast cancer (IBC) is a rare and aggressive subtype. This study analyzes the patterns of failure in patients with IBC treated at our institution. We retrospectively analyzed the records of 227 women with IBC presenting between 1997 and 2011. Survival analysis was used to calculate overall survival (OS) and disease-free survival. Competing risk analysis was used to calculate locoregional recurrence (LRR). A total of 173 patients had locoregional-only disease at presentation (non-MET). Median follow-up in the surviving patients was 3.3 years. Overall, 132 (76.3 %) patients received trimodality therapy with chemotherapy, surgery, and radiotherapy. Three-year OS was 73.1 % [95 % confidence interval (CI) 64.9-82.4]. Cumulative LRR was 10.1, 16.9, and 21.3 % at 1, 2, and 3 years, respectively. No variable was significantly associated with LRR. Fifty-four patients had metastatic disease at presentation (MET). Median follow-up in the surviving patients was 2.6 years. Three-year OS was 44.3 % (95 % CI 31.4-62.5). Twenty-four (44.4 %) patients received non-palliative local therapy (radiotherapy and/or surgery). For these patients, median OS after local therapy was 2 years. Excluding six patients who received local therapy f...Continue Reading

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Citations

Dec 20, 2016·Scientific Reports·Steven G AllenSofia D Merajver
Feb 21, 2018·Breast Cancer Research and Treatment·Anna WeissGildy Babiera
Aug 16, 2019·Current Oncology Reports·Jennifer M Rosenbluth, Beth A Overmoyer
Sep 18, 2016·Annals of Surgical Oncology·Ashley B SimpsonStephanie A Valente
Jan 7, 2021·Annals of Surgical Oncology·Natalia PartainAnthony Lucci

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