Inflammatory caspase-related pyroptosis: mechanism, regulation and therapeutic potential for inflammatory bowel disease

Gastroenterology Report
Yuan-Yuan YuanLian-Wen Yuan

Abstract

As an essential part of programmed cell death, pyroptosis is an inflammatory response that is elicited upon infection by intracellular pathogens. Metabolic diseases, atherosclerosis and vital organ damage occur if pyroptosis is over-activated. Macrophages are the main cells that induce pyroptosis with the help of intracellular pattern-recognition receptors stimulated by danger signals and pathogenic microorganisms in the cytosol of host cells. Activated inflammatory caspases induce pyroptosis and produce pro-inflammatory cytokines, such as interleukin-1β and interleukin-18. Inflammatory programmed cell death is classified as canonical or non-canonical based on inflammatory caspases, which includes caspase-1 (in human and mouse) and caspase-11 (in mouse) or caspase-4 and -5 (in humans). Activated inflammatory caspases cleave the pore-forming effector protein, gasdermin-D, inducing osmotic pressure deregulation of internal fluids and subsequently rupturing the cell membranes. Inflammatory caspases could be attractive therapeutic targets for inflammatory bowel disease (IBD) in which pyroptosis may play an important role. This article reviews the current understanding of the mechanism of pyroptosis, focusing on the regulation of in...Continue Reading

References

Oct 13, 2000·Molecular Microbiology·M A Brennan, B T Cookson
Apr 17, 2001·Trends in Microbiology·B T Cookson, M A Brennan
Jun 11, 2004·Nature·Sanjeev MariathasanVishva M Dixit
Feb 11, 2005·Current Opinion in Gastroenterology·Gerhard Rogler
Mar 25, 2006·Nature Reviews. Immunology·Richard M Siegel
Sep 16, 2006·Cell Death and Differentiation·F Martinon, J Tschopp
Dec 13, 2007·Nature Reviews. Molecular Cell Biology·Rebecca C TaylorSeamus J Martin
Mar 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Susan L FinkBrad T Cookson
Jul 8, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Indrajit ChowdhuryGanapathy K Bhat
Oct 22, 2008·Annual Review of Pathology·Grace ChenGabriel Nuñez
Jan 17, 2009·Nature Reviews. Microbiology·Tessa BergsbakenBrad T Cookson
Jan 23, 2009·Nature Immunology·Tilmann BürckstümmerGiulio Superti-Furga
Sep 8, 2009·Microbes and Infection·Linde DuprezPeter Vandenabeele
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Edward A MiaoAlan Aderem
Apr 14, 2010·The Journal of Experimental Medicine·Irving C AllenJenny P-Y Ting
Sep 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohammad Hasan ZakiThirumala-Devi Kanneganti
Sep 28, 2010·Inflammatory Bowel Diseases·Simon A HirotaPaul L Beck
Jan 12, 2011·Annual Review of Immunology·Beckley K DavisJenny P-Y Ting
Mar 9, 2011·The Journal of Clinical Investigation·Jianxin FuLijun Xia
May 13, 2011·Science Translational Medicine·Yvonne DombrowskiJürgen Schauber
Jul 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·John-Demian SauerDaniel A Portnoy
Aug 31, 2011·Immunology and Cell Biology·Hye-Mi LeeEun-Kyeong Jo
Sep 3, 2011·Immunological Reviews·Edward A MiaoAlan Aderem
Oct 18, 2011·Nature·Nobuhiko KayagakiVishva M Dixit
Oct 19, 2011·Gastroenterology·Grace Y Chen, Gabriel Núñez
Feb 9, 2012·Journal of Experimental & Clinical Cancer Research : CR·Bao xiang WangNi Yin
Mar 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mikhail A GavrilinAmal O Amer
Jul 4, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martina KovarovaBeverly H Koller
Jan 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Christopher L CaseCraig R Roy
May 25, 2013·Nature Reviews. Immunology·Eicke LatzAndrea Stutz
Jun 22, 2013·Cold Spring Harbor Perspectives in Biology·Marcin PorebaMarcin Drag

❮ Previous
Next ❯

Citations

Jun 8, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Zahra Tavakoli Dargani, Dinender K Singla
Apr 1, 2020·Frontiers in Cell and Developmental Biology·Shanshan HuangPeng Zhang
Jun 9, 2020·Frontiers in Immunology·Ethan S FitzGeraldAmanda M Jamieson
Nov 19, 2019·Oxidative Medicine and Cellular Longevity·Tianze ZhangGuangquan Xu
Jan 8, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jiasi WuXianli Meng
Dec 20, 2020·International Journal of Biological Macromolecules·Qijuan SunChen-Guang Liu
Dec 29, 2020·Journal of Advanced Research·Abdullah Al MamunJian Xiao
Apr 19, 2020·International Immunopharmacology·Abdullah Al MamunJian Xiao
Nov 4, 2020·Cells·Nafiseh Chalabi Hagkarim, Roger J Grand
Nov 8, 2020·Current Opinion in Immunology·Ashley WeirJames E Vince
Oct 17, 2019·Cell Reports·Aly A KhanAlexander Chervonsky
Oct 17, 2020·Journal of Molecular Cell Biology·Lu LiXiawei Wei
Jul 6, 2021·Journal of Clinical Periodontology·Pengfei ZhaoQi Wang
Oct 16, 2021·Journal of Molecular Biology·Yinan WeiZhenyu Li
Dec 14, 2021·Frontiers in Cell and Developmental Biology·Liuhua ZhouLiansheng Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPases
IEC

Related Concepts

Related Feeds

Caspases in Metabolic Diseases

Caspases, the family of cysteine proteases are involved in programmed cell death, but their role in metabolic diseases, inflammation and immunity has been of interested. Discover the latest research on caspases in metabolic diseases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.