PMID: 7536846Jan 1, 1995Paper

Inflammatory cell infiltrate associated with primary and transplanted tumours in an inbred model of oral carcinogenesis

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
D W ThomasS S Prime

Abstract

This study characterised the nature of the local cellular immune responses associated with an inbred animal model of oral carcinogenesis. Inbred F344 rats developed moderately- to well-differentiated primary oral squamous cell carcinomas (SCC) after treatment with the carcinogen 4-nitroquinoline N-oxide (4-NQO) in vivo for 5-6 months. The inflammatory cell infiltrate associated with the primary tumours was predominantly of the macrophage lineage (CD45+, Ia+) and contained smaller numbers of CD8+ cells (NK cells, cytotoxic/suppressor T cells), CD5+ cells (T cells) and CD25+ cells (activated cells; T and NK cells). Keratinocyte cell lines were established from three lingual and one palatal SCC. By contrast to normal keratinocytes, tumour-derived cell lines were immortal and independent of 3T3 fibroblast support. All of the tumour-derived cell lines were tumorigenic in athymic (nu/nu) mice and showed contrasting latent periods of tumour development and histological differentiation; normal keratinocyte grafts were non-tumorigenic in athymic mice. Three of four malignant cell lines formed well-differentiated tumours in syngeneic F344 rats; the tumours regressed after 10-14 days. Regressing grafts contained significantly larger numbe...Continue Reading

References

Oct 1, 1991·The Journal of Pathology·S MutluS S Prime
Oct 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M Bryne
Mar 1, 1988·Journal of Oral Pathology·A Pitigala-ArachchiS S Prime
Feb 1, 1989·Immunology Letters·G Berke
Jan 1, 1989·Advances in Immunology·G Trinchieri
Jan 1, 1989·Archives of Surgery·R T Prehn, L M Prehn
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·J B MatthewsS S Prime
Jan 1, 1987·Cancer Immunology, Immunotherapy : CII·R L KradinJ T Kurnick
Jan 1, 1987·Cancer Immunology, Immunotherapy : CII·S P SchantzN Beddingfield
Jan 1, 1993·Head & Neck·G CortesinaA De Stefani

❮ Previous
Next ❯

Citations

Nov 4, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Hamid R DjalilianFrank G Ondrey
Nov 24, 2006·Journal of Dental Research·A JewettN A Cacalano
Apr 1, 1996·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·D W ThomasS S Prime
Jan 31, 2019·Oncogene·Carlos Rossa, Nisha J D'Silva

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.