Inflammatory Cell Infiltrates in Acute and Chronic Thoracic Aortic Dissection

Aorta : Official Journal of the Aortic Institute at Yale-New Haven Hospital
Darrell WuScott A LeMaire

Abstract

Thoracic aortic dissection (TAD) is a highly lethal cardiovascular disease. Injury to the intima and media allows pulsatile blood to enter the media, leading to dissection formation. Inflammatory cells then infiltrate the site of aortic injury to clear dead cells and damaged tissue. This excessive inflammation may play a role in aneurysm formation after dissection. Using immunohistochemistry, we compared aortic tissues from patients with acute TAD (n = 11), patients with chronic TAD (n = 35), and donor controls (n = 20) for the presence of CD68+ macrophages, neutrophils, mast cells, and CD3+ T lymphocytes. Tissue samples from patients with acute or chronic TAD generally had significantly more inflammatory cells in both the medial and adventitial layers than did the control samples. In tissues from patients with acute TAD, the adventitia had more of the inflammatory cells studied than did the media. The pattern of increase in inflammatory cells was similar in chronic and acute TAD tissues, except for macrophages, which were seen more frequently in the adventitial layer of acute TAD tissue than in the adventitia of chronic TAD tissue. The inflammatory cell content of both acute and chronic TAD tissue was significantly different f...Continue Reading

Citations

Sep 8, 2018·Experimental Physiology·Shanshan WangJingang Zheng
Apr 24, 2020·Journal of Cardiovascular Pharmacology and Therapeutics·Sheng LeJiahong Xia
Aug 25, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Toshihiro TsurudaKazuo Kitamura
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