Inflammatory cells in experimental intervertebral disc injury

Spine
A KanervaE Karaharju

Abstract

Inflammatory cells were located by immunocytochemistry in areas of experimental intervertebral disc injury in pigs. To study the occurrence of T lymphocytes and macrophages 1 week, 1 month, and 3 months after partial-thickness transverse scalpel injuries in pig lumbar discs. Inflammatory cells and mediators recently have been observed in disc herniation tissue that was removed at disc prolapse surgery. The prevalence of inflammatory cell infiltrates in such clinical disc tissue material also has been studied. There are no studies, however, that have analyzed, using immunocytochemical methodology, the occurrence of, types of, and time dependence of inflammatory cells in an experimental disc injury model. The role of inflammation in intervertebral disc injury and repair has not been determined. Transverse scalpel injuries 5-mm long and 4-mm deep were cut in the anterolateral anulus of L5-L6 and L4-L5 discs in 16 pigs. The cuts in the center of the anulus did not reach the nucleus pulposus and never produced a disc prolapse. In every pig, two non-adjacent lumbar discs (L1-L2 and L2-L3) were used as controls. Four discs per animal were studied in parallel by two different complementary immunohistochemical staining protocols. T lymp...Continue Reading

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Citations

Aug 4, 2004·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Srinivasu KallakuriJohn M Cavanaugh
Apr 6, 2005·Neurosurgical Review·Orhan SenNur Altinors
Jan 16, 2014·The Indian Journal of Surgery·Sibel Akyol, Murat Hancı
Jan 5, 2007·Spine·Marc-Antoine A RousseauJeffrey C Lotz
Jul 15, 2015·Experimental and Therapeutic Medicine·Peng TianXin-Long Ma
Jan 18, 2016·Journal of Orthopaedic Surgery and Research·Hongqiang JiangXinlong Ma
Oct 26, 2010·The Spine Journal : Official Journal of the North American Spine Society·Aliza A AllonJeffrey C Lotz
Sep 30, 2009·Journal of Magnetic Resonance Imaging : JMRI·Guillaume BierryStéphane Kremer
Sep 29, 2009·Veterinary Surgery : VS·Angela B RoyalLinda M Berent
May 8, 2013·Journal of Veterinary Internal Medicine·A FaddaD Henke
Jun 14, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Liufang JingJun Chen
May 4, 2002·Best Practice & Research. Clinical Rheumatology·Bruce L Kidd, Peter M Richardson
Oct 28, 2016·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Stefan DudliJeffrey C Lotz
Jan 4, 2019·Annals of the New York Academy of Sciences·Olivia M TorreJames C Iatridis
Sep 11, 2020·Tissue Engineering. Part B, Reviews·Ana P PeredoRobert L Mauck

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