Inflammatory Contribution of Platelets Revisited: New Players in the Arena of Inflammation

Seminars in Thrombosis and Hemostasis
Madhumita Chatterjee, Tobias Geisler

Abstract

Platelet-derived mediators, either in an autocrine or paracrine mode of action, regulate systemic and vascular inflammation as well as contribute to innate immune defense and also to regenerative mechanisms. This review reevaluates the impact of inflammatory mediators such as CXC-chemokine-Ligands, their receptors in modulating platelet functions and platelet survival, thereby influencing inflammatory or regenerative processes. We further explore the contribution of cyclophilin A and C-reactive protein in regulating thrombotic and hemostatic attributes of platelets. Moreover, we emphasize on the role of platelets as active components bridging the innate and adaptive immune responses, toll-like receptors on platelets, platelet interactions with the complement system, and platelet-derived thrombocidins exhibiting direct antimicrobial properties. As highlighted in this review, the multifaceted aspects of platelets and platelet-derived factors encourage further investigations in this intriguing and expansive but largely uncharted area of research in platelet biology.

Citations

May 12, 2016·Cell Metabolism·Garret A FitzGerald
Jul 22, 2017·Cancer Metastasis Reviews·David G MenterKenneth V Honn
Sep 1, 2018·Frontiers in Immunology·Perrine BortolottiEric Kipnis
Apr 22, 2020·Proceedings·Somedeb BallKenneth Nugent
May 10, 2017·Clinical Hemorheology and Microcirculation·Judit TóthJános Kappelmayer
Jul 17, 2020·Frontiers in Cardiovascular Medicine·Patricia B MaguireMeinrad Gawaz
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Jul 27, 2018·Research and Practice in Thrombosis and Haemostasis·Jerry Ware, Kottayil I Varughese
Oct 30, 2020·International Journal of Molecular Sciences·Madhumita ChatterjeeMargitta Elvers
Jan 14, 2022·Cancer Metastasis Reviews·David G MenterAnil K Sood

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