Inflammatory cytokine release is affected by surface morphology and chemistry of titanium implants

Journal of Materials Science. Materials in Medicine
Anna-Karin ÖstbergCarina B Johansson

Abstract

To investigate in vitro cellular cytokine expression in relation to commercially pure titanium discs, comparing a native surface to a fluorinated oxide nanotube surface. Control samples pure titanium discs with a homogenous wave of the margins and grooves and an often smeared-out surface structure. Test samples pure titanium discs with a fluorinated titanium oxide chemistry and surface morphology with nanopore/tube geometry characterized by ordered structures of nanotubes with a diameter of ≈ 120 nm, a spacing of ≈ 30 nm, and a wall thickness of ≈ 10 nm. Cross-section view showed vertically aligned nanotubes with similar lengths of ≈ 700 nm. Peripheral blood mononuclear leucocytes were cultured for 1, 3, and 6 days according to standard procedures. BioPlex Pro™ assays were used for analysis and detection of cytokines. Selected inflammatory cytokines are reported. A pronounced difference in production of the inflammatogenic cytokines was observed. Leucocytes exposed to control coins produced significantly more TNF-α, IL-1ß, and IL-6 than the test nanotube coins. The effect on the TH2 cytokine IL-4 was less pronounced at day 6 compared to days 1 and 3, and slightly higher expressed on the control coins. The morphology and surface...Continue Reading

References

Jan 10, 2003·Clinical Oral Implants Research·Pericles SpyrouFraser McDonald
Jul 1, 2004·Journal of Biomedical Materials Research. Part a·Ali K RefaiJ Douglas Waterfield
Mar 27, 2007·Injury·Eleftherios TsiridisPeter Giannoudis
May 17, 2007·Nano Letters·Jung ParkPatrik Schmuki
Feb 7, 2008·Nano Letters·Karla S BrammerSungho Jin
May 13, 2008·Journal of Biomedical Materials Research. Part a·Young-Taeg SulTomas Albrektsson
Jul 12, 2008·Biomaterials·Gustavo MendonçaLyndon F Cooper
Sep 10, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Cornelius von WilmowskyKarl Andreas Schlegel
Nov 7, 2008·Journal of Biomedical Materials Research. Part a·Kristy M AinslieTejal A Desai
Jan 15, 2010·Clinical Oral Implants Research·Po-Chun ChangWilliam V Giannobile
Sep 28, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Christine A St PierreRobert W Finberg
Apr 15, 2011·Injury·Richard Marsell, Thomas A Einhorn
Jul 5, 2011·Clinical Oral Implants Research·Carina B JohanssonElisabet Ahlberg
May 23, 2012·Journal of Biomedical Materials Research. Part a·Humberto Osvaldo Schwartz-FilhoRosemary Adriana Chiérici Marcantonio
Jan 26, 2013·Journal of Biomedical Materials Research. Part a·Sandra C P CachinhoJohn A Hunt
Jul 24, 2013·Inflammation & Allergy Drug Targets·Durgaprasad LavetiRavinder Nagpal
Mar 22, 2014·Biomedical Reports·Xixi Ma, Shengqian Xu
Sep 16, 2014·The International Journal of Biochemistry & Cell Biology·Patricia NeacsuIoana Demetrescu

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Citations

Jan 11, 2018·International Journal of Environmental Research and Public Health·Violetta BorelliGiuliano Zabucchi
Jun 28, 2016·Journal of Materials Science. Materials in Medicine· SunarsoKunio Ishikawa
Mar 4, 2021·Nanomaterials·Erin A BakerCraig R Friedrich

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