Inflammatory cytokine response following acute tibial plateau fracture

The Journal of Bone and Joint Surgery. American Volume
Justin M HallerThomas F Higgins

Abstract

The objective of the present study was to evaluate human synovial fluid for inflammatory cytokine concentrations following acute tibial plateau fracture. Our hypothesis was that there would be an elevated inflammatory response following intra-articular fracture, and that the inflammatory response would be greater after high-energy compared with low-energy injuries. Between December 2011 and June 2013, we prospectively enrolled forty-five patients with an acute tibial plateau fracture. Synovial fluid aspirations were performed on the injured and uninjured knees. Twenty patients who required an external fixator followed by delayed fixation underwent aspiration at both surgical procedures. The concentrations of interferon-gamma (IFN-γ), interleukin-1 beta (IL-1β), interleukin-1 receptor antagonist (IL-1RA), IL-2, IL-4, IL-6, IL-7, IL-8, IL-10, IL-12(p70), IL-13, IL-17A, tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-1 beta (MIP-1β) were quantified with use of multiplex assays. The forty-five patients had an average age of forty-two years (range, twenty to sixty years). There were twenty-four low-energy and twenty-one high-energy tibial plateau injuries. There wa...Continue Reading

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Citations

Jul 15, 2015·Clinical Orthopaedics and Related Research·Justin M HallerThomas F Higgins
Feb 2, 2017·Foot & Ankle International·Samuel B AdamsDana L Nettles
Apr 4, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Justin M HallerThomas F Higgins
Dec 3, 2016·Bone & Joint Research·K S RakhraP E Beaule
Dec 29, 2016·The Journal of the American Academy of Orthopaedic Surgeons·Mitchell BernsteinS Robert Rozbruch
Apr 10, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Erman ChenZhijun Pan
Nov 11, 2017·Acta orthopaedica et traumatologica turcica·Adel EbrahimpourMohammad-Reza Minator Sajjadi
Oct 27, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michael W BuchananSteven A Olson
Dec 1, 2019·Journal of Shoulder and Elbow Surgery·Elizabeth P WahlMarc J Richard
Mar 1, 2021·Osteoarthritis and Cartilage·B D FurmanS A Olson

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