Inflammatory cytokines and oxidative stress biomarkers in irritable bowel syndrome: Association with digestive symptoms and quality of life

Cytokine
Razieh ChoghakhoriR Amani

Abstract

A growing body of evidence suggests a possible role for low-grade inflammation in the pathogenesis of irritable bowel syndrome (IBS). The objectives of this study were to measure serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-17, interleukin (IL)-10, malondialdehyde (MDA) and total antioxidant capacity (TAC) in IBS patients and healthy controls (HCs), and to evaluate possible correlations of such markers with gastrointestinal (GI) symptoms and quality of life (QoL). Ninety Rome III positive IBS patients and 90 sex and age matched HCs were recruited. GI symptoms, IBS-QoL, IBS severity score system (IBSSS), and the serum levels of inflammatory cytokines and oxidative stress biomarkers were evaluated. In IBS patients, TNFα, IL-17 and MDA cytokines were significantly (P<0.05) higher, and IL-10 cytokine and TAC were significantly (P<0.05) lower vs. HCs. When comparing IBS subtypes, TNFα and IL-17 were significantly (P<0.05) higher, and IL-10 was significantly (P<0.05) lower in diarrhea predominant IBS (IBS-D) compared to HCs, whereas the inflammatory cytokine profile of other subtypes more closely resembled that of HCs. The serum levels of MDA and TAC were significantly different (P<0.05) in all the subtypes vs. HCs...Continue Reading

Citations

Sep 27, 2018·Journal of the American College of Nutrition·Amir AbbasnezhadRazieh Choghakhori
Aug 11, 2018·Psychosomatic Medicine·Johannes PeterGabriele Moser
Feb 13, 2019·Minerva gastroenterologica e dietologica·Prianka Gajula, Eamonn M Quigley
Aug 8, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Kenneth Man-Fung WongJustin Che-Yuen Wu
Dec 4, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·Andrew CanakisHorst Christian Weber
Oct 16, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Yu ZhangWei-Juan Gong
May 29, 2020·Journal of Cosmetic Dermatology·Abdullah Demirbaş, Ömer Faruk Elmas
Aug 5, 2020·Expert Opinion on Drug Discovery·Taraneh MousaviMohammad Abdollahi
Aug 26, 2018·European Child & Adolescent Psychiatry·Kasia KozlowskaEllis Patrick
Jul 6, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Nazanin Momeni RoudsariAmir Hossein Abdolghaffari
Apr 22, 2020·Therapeutic Advances in Gastroenterology·Maite Casado-Bedmar, Åsa V Keita
Aug 9, 2018·Journal of Clinical Biochemistry and Nutrition·Akinori Yanaka
Sep 29, 2020·Journal of Biomedical Science·Lesha Pretorius, Carine Smith
Sep 24, 2019·Indian Journal of Dermatology·Z Gizem Kaya İslamoğluAdem Küçük
Jun 23, 2020·Oxidative Medicine and Cellular Longevity·Ioana-Miruna BalmusLucian Gorgan
Oct 6, 2020·Frontiers in Cellular and Infection Microbiology·Caterina CarcoNicole C Roy
Aug 29, 2018·Journal of Clinical Medicine·Stephanie BalikjiJoris C Verster
Oct 28, 2019·Pain·Elina Iordanova SchistadChristopher Sivert Nielsen
Dec 19, 2020·Psychosomatic Medicine·Marianna GasperiNiloofar Afari
Nov 30, 2020·Brain, Behavior, and Immunity·Anna-Karin NorlinMaria Engström
Mar 7, 2021·International Journal of Environmental Research and Public Health·Jongmin ParkChang Won Won
Dec 2, 2020·Ecotoxicology and Environmental Safety·Yinan WangMaoyong Song
Jun 6, 2021·Hormone Molecular Biology and Clinical Investigation·Shima LorestaniFarnaz Zahedi Avval
Jun 11, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mohamed ElbadawiThomas Efferth
Sep 24, 2021·International Journal of Clinical Practice·Munise DayeBerna Hafızoğlu
Oct 9, 2021·Journal of Medicine and Life·Yuliya Vyacheslavivna BilookaOleksandr Vyacheslavovich Bilookyi

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