Inflammatory cytokines and peripheral mediators in the pathophysiology of pruritus in cutaneous T-cell lymphoma

Journal of the European Academy of Dermatology and Venereology : JEADV
D J LewisMadeleine Duvic

Abstract

Cutaneous T-cell lymphoma (CTCL) includes a diverse group of neoplasms, including mycosis fungoides and Sézary syndrome. One of the earliest and most common symptoms of CTCL is pruritus, which affects up to 88% of patients. The severity of pruritus can range from mild to very debilitating, producing tremendous discomfort and a significant decrease in quality of life. Patients with advanced disease, in particular, may experience a more chronic, intractable pruritus. However, the underlying mechanism of pruritus in CTCL remains unknown. Conventional antipruritic agents, such as antihistamines, gamma-aminobutyric acid analogs and antidepressants, are only partially effective in relieving symptoms, suggesting a more complex, unique pathophysiology. In this review, we summarize the current research on cytokines and peripheral mediators implicated in pruritus in CTCL.

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Citations

Dec 16, 2019·British Medical Bulletin·Emanuele ChisariNicola Maffulli
Mar 3, 2020·Journal of Pain & Palliative Care Pharmacotherapy·Hannah BrombergDavid Craig
Jul 10, 2020·International Journal of Dermatology·Berenika OlszewskaMałgorzata Sokołowska-Wojdyło
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Veronica StolearencoThorbjørn Krejsgaard
Oct 18, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·O SteckC Schlapbach
Apr 4, 2021·Vaccines·Simone GarcovichGiampiero Girolomoni
Apr 21, 2019·The Journal of Allergy and Clinical Immunology·Takashi Hashimoto, Gil Yosipovitch
May 24, 2021·The Journal of Investigative Dermatology·Takashi HashimotoGil Yosipovitch
May 26, 2021·Experimental Dermatology·Giuseppe IngrasciGil Yosipovitch
Aug 28, 2021·Nature Reviews. Disease Primers·Reinhard DummerEgle Ramelyte

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