Inflammatory Cytokines and Sleep Disturbance in Patients with Temporomandibular Disorders

Journal of Oral & Facial Pain and Headache
Ji Woon Park, Jin Woo Chung

Abstract

To assess the degree and interrelationship of sleep disturbance and plasma cytokine levels in temporomandibular disorder (TMD) pain patients. Forty female TMD patients and 20 age-, sex-, and body mass index (BMI)-matched healthy subjects were enrolled. TMD was diagnosed using the Research Diagnostic Criteria for TMD. The TMD patients were classified as having low or high disability according to Graded Chronic Pain Scale findings. The Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) were used to measure sleep quality. Plasma concentrations of interleukin (IL)-1β, IL-6, IL-10, tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) were measured from blood samples collected between 9 am and noon. Statistical analyses included Kruskal-Wallis and one-way analysis of variance tests to compare results between different groups and multivariate general linear models to evaluate the effect of sleep status on cytokine levels. The high-disability group had the highest PSQI and ESS scores (P < .001). Plasma levels of IL-1β, IL-6, IL-10, and TNF-α were significantly higher in the patient groups, with the high-disability group exhibiting the highest values (P ≤ .001). The plasma cytokine levels were significantl...Continue Reading

Citations

Jul 17, 2016·Journal of Dental Research·D E HarperD J Clauw
Jan 23, 2018·Metabolic Syndrome and Related Disorders·Mingzhen LiLiming Chen
Nov 28, 2018·Cranio : the Journal of Craniomandibular Practice·Hee Jin Lee, Seong Taek Kim
Nov 24, 2018·Head & Face Medicine·Ji Rak KimJi Woon Park
Jun 1, 2018·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Malgorzata PihutAndrzej Gala
Jun 20, 2020·Cranio : the Journal of Craniomandibular Practice·Leanna BlanchardAlison Duncombe
Oct 3, 2018·Cranio : the Journal of Craniomandibular Practice·Supawadee Jariyasakulroj, Somsak Mitrirattanakul
Sep 3, 2020·International Journal of Environmental Research and Public Health·Ju-Hui WuMing-Ju Tsai
Mar 1, 2017·The Journal of Headache and Pain·S Louca JoungerM Ernberg
Nov 6, 2020·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Samilla Pontes BragaPaulo César Rodrigues Conti
Jul 30, 2021·Journal of Leukocyte Biology·Yating YiJun Wang
Aug 14, 2021·Journal of Photochemistry and Photobiology. B, Biology·Eliana de Souza Bastos Mazuqueli PereiraJuliana Trindade Clemente-Napimoga
Oct 3, 2021·Journal of Oral Rehabilitation·Camila Caspary RoithmannMárcio Lima Grossi

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