Inflammatory Cytokines Are Involved in Focal Demyelination in Leprosy Neuritis

Journal of Neuropathology and Experimental Neurology
Priscila Ribeiro AndradeEuzenir N Sarno

Abstract

Mycobacterium leprae (ML) infection causes nerve damage that often leads to permanent loss of cutaneous sensitivity and limb deformities, but understanding of the pathogenesis of leprous neuropathy that would lead to more effective treatments is incomplete. We studied reactional leprosy patients with (n = 9) and without (n = 8) acute neuritis. Nerve conduction studies over the course of the reactional episode showed the findings of demyelination in all patients with neuritis. Evaluation of patient sera revealed no correlation of the presence of antibodies against gangliosides and the clinical demyelination. In nerve biopsies of 3 patients with neuritis, we identified tumor necrosis factor (TNF), TNF receptors, and TNF-converting enzyme in Schwann cells (SCs) using immunofluorescence. To elucidate immunopathogenetic mechanisms, we performed experiments using a human SC line. ML induced transmembrane TNF and TNF receptor 1 expression in the SCs; TNF also induced interleukin (IL)- 6 and IL-8 production by the SCs; and ML induced IL-23 secretion, indicating involvement of this previously unrecognized factor in leprosy nerve damage. These data suggest that ML may contribute to TNF-mediated inflammation and focal demyelination by ren...Continue Reading

References

Apr 1, 1992·Infection and Immunity·P F BarnesR L Modlin
Jan 1, 1991·Genes, Chromosomes & Cancer·T W GloverS Johnson
Mar 1, 1987·Infection and Immunity·L D SibleyJ L Krahenbuhl
Dec 2, 1999·Journal of Neuroimmunology·J L RutkowskiS L Kunkel
Apr 1, 2000·Journal of Neuropathology and Experimental Neurology·B BonettiG Moretto
Jul 20, 2000·Journal of Neuroimmunology·M LiefnerW Brück
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria L OllerosIrene Garcia
Nov 7, 2002·Archives of Dermatological Research·Rosane M B TelesElizabeth P Sampaio
Nov 14, 2002·Brain : a Journal of Neurology·Hugh J Willison, Nobuhiro Yuki
Jan 1, 2003·Muscle & Nerve·Richard K OlneyUNKNOWN American Association of Electrodiagnostic Medicine
Oct 22, 2003·Journal of the Neurological Sciences·Jifen LiMalek Kamoun
May 7, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William B J CaffertyStephen W N Thompson
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bernadette M SaundersWarwick J Britton
Oct 11, 2005·Journal of Neuropathology and Experimental Neurology·Rosane B OliveiraEuzenir N Sarno
Nov 22, 2005·Molecular and Cellular Neurosciences·Veronica I ShubayevRobert R Myers
Jun 14, 2006·Archives of Neurology·Wei HuBernd C Kieseier
Dec 27, 2006·Brain, Behavior, and Immunity·Sharmila ChattopadhyayVeronica Shubayev
Jan 6, 2007·Brain, Behavior, and Immunity·Nurcan UçeylerClaudia Sommer
Apr 25, 2007·Critical Reviews in Microbiology·Tahziba Hussain
Sep 18, 2007·Journal of the Peripheral Nervous System : JPNS·Rosane M B TelesEuzenir N Sarno
Jul 29, 2008·Memórias do Instituto Oswaldo Cruz·Tatiana Pereira da SilvaEuzenir Nunes Sarno
Dec 23, 2008·Arquivos de neuro-psiquiatria·José Antonio GarbinoBernard Naafs
Dec 17, 2009·Journal of Neuropathology and Experimental Neurology·Ariane Leite OliveiraEuzenir Nunes Sarno
Apr 9, 2011·Journal of Neuroimmunology·Ana CamineroXavier Montalban
Oct 18, 2011·Trends in Neurosciences·Conor Mc GuireGeert van Loo
Mar 15, 2012·Memórias do Instituto Oswaldo Cruz·Sérgio Luiz Gomes AntunesEuzenir Nunes Sarno
Feb 15, 2013·The European Journal of Neuroscience·Bruno Siqueira MiettoAna Maria Blanco Martinez
Jul 9, 2013·Journal of Comparative Pathology·A H CrawfordR J M Franklin
Nov 28, 2013·Cellular Reprogramming·Toshihiro MasakiAnura Rambukkana
May 31, 2014·Multiple Sclerosis : Clinical and Laboratory Research·S RossiD Centonze
Feb 7, 2015·Clinical Neurology and Neurosurgery·M R JardimX Illarramendi
Feb 11, 2015·Expert Review of Clinical Immunology·Priscila Ribeiro AndradeEuzenir Nunes Sarno

❮ Previous
Next ❯

Citations

Sep 26, 2019·Journal of Medical Microbiology·Ruchi RastogiJagdeep Kaur
Apr 13, 2018·Frontiers in Immunology·Roberta Olmo PinheiroEuzenir Nunes Sarno
Nov 27, 2020·International Reviews of Immunology·Luis Alberto Ribeiro FroesMirian Nacagami Sotto
Dec 22, 2020·Muscle & Nerve·Sérgio Luiz Gomes AntunesAmilton Antunes Barreira
Aug 25, 2021·BMC Infectious Diseases·Louise Mara GieselMarcia Rodrigues Jardim
Nov 20, 2021·PloS One·Márcia JardimEuzenir N Sarno

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association
I KaurN K Ganguly
Journal of Neuropathology and Experimental Neurology
Rosane B OliveiraEuzenir N Sarno
Microbial Pathogenesis
Tinara Leila de Sousa AarãoJuarez Antonio Simões Quaresma
© 2022 Meta ULC. All rights reserved