PMID: 8988847Nov 1, 1996Paper

Inflammatory cytokines in animal health and disease

Veterinary Immunology and Immunopathology
M P MurtaughG Lin

Abstract

Inflammatory cytokines, including tumor necrosis factor (TNF), interleukin-1 (IL-1), IL-6 and IL-8, are rapidly induced early in a disease or injury process. They mediate and modulate myriad healing processes but, if overexpressed, may exacerbate the severity of a disease condition. In order to test this concept and to establish a foundation for the role of inflammatory cytokines in the pathogenesis of gram-negative bacterial infections in the respiratory tract of animals, the patterns of inflammatory cytokine expression were determined in experimental porcine pleuropneumonia. We observed that IL-1 and IL-6, but not TNF, were rapidly and dramatically elevated in the lavage fluid of the lung within 24 h of infection. The increased levels of IL-1 might contribute to increased severity of disease, but elevated IL-6 levels were consistent with a protective acute phase response. Additional studies were performed to examine the hypothesis that IL-4 expression later in infection might be involved in turning off the inflammatory response and promoting an antigen-specific humoral immune response. Interleukin-4 efficiently suppressed inflammatory cytokine production in alveolar macrophages. Its expression was induced in peripheral blood ...Continue Reading

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Citations

Apr 28, 2000·Developmental and Comparative Immunology·G A Harrison, D N Wedlock
Apr 13, 2000·Veterinary Immunology and Immunopathology·N R ReddyB N Wilkie
Jun 20, 2002·Veterinary Immunology and Immunopathology·Kristien Van ReethMaurice Pensaert
Oct 31, 2002·Veterinary Immunology and Immunopathology·F J SalgueroJ C Gómez-Villamandos
Nov 5, 2002·Veterinary Microbiology·John H Wyckoff
Oct 1, 2000·Avian Pathology : Journal of the W.V.P.A·M H Kogut
Mar 14, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Massimo Amadori
Jun 16, 2009·Journal of Orthopaedic Surgery and Research·R YogaW Sutherland
Jul 4, 2007·American Journal of Veterinary Research·Pedro J Sánchez-CordónJosé C Gómez-Villamandos
May 23, 2009·The Veterinary Clinics of North America. Food Animal Practice·Sanjay KapilJames F Evermann
Jan 23, 2009·Veterinary Immunology and Immunopathology·Wasin Charerntantanakul
Sep 29, 2007·Journal of Immunological Methods·Charlotte A AllenKaren E Russell
Apr 3, 2007·Journal of Comparative Pathology·M PedreraJ C Gómez-Villamandos
Oct 28, 2004·Veterinary Immunology and Immunopathology·Steven Van GuchtKristien Van Reeth
Aug 25, 2004·Comparative Immunology, Microbiology and Infectious Diseases·A NuntaprasertC Kai
Jul 29, 2015·Forensic Science International : Synergy·Meri TakadaToshiji Mukai
Jun 24, 2015·Veterinary Immunology and Immunopathology·H WynsS Croubels
Oct 8, 2005·The Journal of Veterinary Medical Science·Raadan OdbilegMisao Onuma
Mar 6, 2008·The Journal of Veterinary Medical Science·Raadan OdbilegKazuhiko Ohashi
Mar 8, 2005·The Journal of Veterinary Medical Science·Raadan OdbilegMisao Onuma
Mar 1, 2012·Veterinary Immunology and Immunopathology·Mohammad Ariful IslamKarl Schellander
Aug 4, 2005·Virology Journal·Svend Ellermann-Eriksen
Sep 5, 2009·Toxicology and Applied Pharmacology·Vasanthi R SunilDebra L Laskin

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