Inflammatory cytokines in general and central obesity and modulating effects of physical activity

PloS One
Frank M SchmidtHubertus Himmerich

Abstract

Chronic systemic inflammation in obesity originates from local immune responses in visceral adipose tissue. However, assessment of a broad range of inflammation-mediating cytokines and their relationship to physical activity and adipometrics has scarcely been reported to date. To characterize the profile of a broad range of pro- and anti-inflammatory cytokines and the impact of physical activity and energy expenditure in individuals with general obesity, central obesity, and non-obese subjects. A cross-sectional study comprising 117 obese patients (body mass index (BMI) ≥ 30) and 83 non-obese community-based volunteers. Serum levels of interleukin (IL)-2, IL-4, IL-5, IL-10, IL-12, IL-13, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon (IFN)-γ and tumor necrosis factor (TNF)-α were measured. Physical activity and energy expenditure (MET) were assessed with actigraphy. Adipometrics comprised BMI, weight, abdominal-, waist- and hip-circumference, waist to hip ratio (WHR), and waist-to-height-ratio (WHtR). General obesity was associated with significantly elevated levels of IL-5, IL-10, IL-12, IL-13, IFN-γ and TNF-α, central obesity with significantly elevated IL-5, IL-10, IL-12, IL-13 and IFN-γ-levels. In par...Continue Reading

References

Nov 1, 1994·Diabetologia·T AwataY Kanazawa
Oct 30, 1998·Diabetologia·J C Pickup, M A Crook
Dec 18, 1998·Science·M Wills-KarpD D Donaldson
Aug 31, 2000·Endocrinology·K T UysalG S Hotamisligil
May 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·G FrühbeckM A Burrell
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Katherine EspositoDario Giugliano
Jul 29, 2003·Diabetes·Gunnar EngströmFolke Lindgärde
Sep 2, 2003·Cytokine & Growth Factor Reviews·Hong Ruan, Harvey F Lodish
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Jun 5, 2004·Medicine and Science in Sports and Exercise·Margaret L Fruin, Janet Walberg Rankin
Oct 8, 2004·The British Journal of Nutrition·Paul Trayhurn, I Stuart Wood
May 17, 2005·Journal of the American College of Cardiology·Christos Kasapis, Paul D Thompson
Jul 21, 2005·The Journal of Clinical Endocrinology and Metabolism·M R ManigrassoG Davì
Nov 9, 2005·The Journal of Clinical Investigation·Jacquelyn A ReedRandy J Seeley
Dec 15, 2005·American Journal of Physiology. Endocrinology and Metabolism·Jens M BruunBente Stallknecht
Mar 23, 2006·JAMA : the Journal of the American Medical Association·Samia MoraPaul M Ridker
Apr 22, 2006·American Journal of Respiratory and Critical Care Medicine·David A BeutherE Rand Sutherland
Jan 4, 2007·The Journal of Clinical Investigation·Carey N LumengAlan R Saltiel
Mar 9, 2007·The American Journal of Clinical Nutrition·Maxime St-OngeRémi Rabasa-Lhoret
Jul 7, 2007·The Journal of Nutritional Biochemistry·Sun Hye JungKwan-Woo Lee
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon GaudreauAbdelaziz Amrani
Mar 5, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Marc Y Donath, Thomas Mandrup-Poulsen
May 28, 2008·European Psychiatry : the Journal of the Association of European Psychiatrists·H HimmerichT Pollmächer
Sep 4, 2008·American Journal of Physiology. Endocrinology and Metabolism·Dong-Hoon KimRandy J Seeley
Nov 27, 2008·Clinical and Investigative Medicine. Médecine Clinique Et Experimentale·M CanözS Aydin
May 2, 2009·Journal of Leukocyte Biology·Andrew J FleetwoodJohn A Hamilton
Aug 18, 2009·Molecular and Cellular Endocrinology·E Maury, S M Brichard
Mar 11, 2010·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Janet M WarrenUNKNOWN Experts Panel
Jun 10, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D Martinez-GomezUNKNOWN AFINOS Study Group
Oct 26, 2010·European Journal of Applied Physiology·Clemens Drenowatz, Joey C Eisenmann
Feb 8, 2011·Lancet·Mariel M FinucaneUNKNOWN Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index)
Mar 2, 2011·Diabetes Technology & Therapeutics·Jayagopi SurendarVivekanandhan Aravindhan
Jun 1, 2011·The Journal of Allergy and Clinical Immunology·Fernando HolguinSally E Wenzel
Jun 15, 2011·The Journal of Clinical Investigation·Xudong LiaoMukesh K Jain
Mar 6, 2012·Metabolism: Clinical and Experimental·Robert W O'RourkeDaniel L Marks
May 2, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Derek C LaceyJohn A Hamilton

❮ Previous
Next ❯

Citations

Sep 25, 2016·Current Neurology and Neuroscience Reports·Kevin G BurfeindDaniel L Marks
Apr 13, 2017·European Journal of Clinical Nutrition·K N KeaneP Newsholme
Jul 6, 2016·Diabetes & Metabolic Syndrome·Sandra Maria BarbalhoMarie Oshiiwa
Feb 9, 2017·Journal of Clinical Laboratory Analysis·Derya GuzelAtila Erol
Feb 23, 2017·The Journal of Steroid Biochemistry and Molecular Biology·Geetanjali SharmaEric R Prossnitz
Jul 7, 2017·The Journal of International Medical Research·Katarzyna KaczmarczykAleksander Ronikier
Mar 22, 2016·Physiological Reports·Pia S PetersenG William Wong
Jan 20, 2018·Breast Cancer Research and Treatment·Ting BaoJun J Mao
Dec 21, 2017·CNS Drugs·A Ardura-FabregatY Yang
Jul 6, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Kelsey L McAlisterDaniela A Rubin
Mar 2, 2018·Journal of Neuroinflammation·María Juncal-RuizBenedicto Crespo-Facorro
Mar 2, 2019·British Journal of Pharmacology·Darren C HenstridgeMark A Febbraio
May 21, 2019·Endocrinology·Aaron R CoxSean M Hartig
Jul 25, 2019·American Journal of Veterinary Research·Jamie J KopperVanessa L Cook
Jul 20, 2016·The American Journal of Chinese Medicine·Feifei MaFeng Wang
Oct 28, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Kelsey H CollinsDavid A Hart
Sep 5, 2019·Scandinavian Journal of Medicine & Science in Sports·Pedro Acosta-ManzanoVirginia A Aparicio
Oct 10, 2019·American Journal of Physiology. Cell Physiology·Natasha ChernisSean M Hartig
Jan 30, 2018·Journal of Alzheimer's Disease : JAD·W M A D Binosha FernandoUNKNOWN AIBL Research Group
Nov 28, 2019·Current Hypertension Reports·Mariana Rodrigues Pioli, Ana Paula de Faria
Feb 7, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gabriela Martínez-ChacónSari Mäkelä
Feb 7, 2020·Cells·Marion Rolot, Timothy E O'Sullivan
Feb 6, 2020·Metabolites·Inês BrandãoRosário Monteiro
Jan 1, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V N ShahJ K Snell-Bergeon
Jul 28, 2016·Diabetology & Metabolic Syndrome·Monica C SerraAlice S Ryan
Jul 25, 2019·Immunity & Ageing : I & a·Bolaji Lilian Ilesanmi-OyelereMarlena Cathorina Kruger
Jul 20, 2020·The American Journal of Tropical Medicine and Hygiene·Rita de Cássia Menezes SoaresLetícia Martins Raposo
Jun 21, 2017·Hormone Molecular Biology and Clinical Investigation·Khageshwar MahatoBinita Goswami
Sep 29, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gagandeep BrarManish A Shah
Jan 21, 2016·Annals of Clinical Biochemistry·Maryam AzizianMajid Ghayour-Mobarhan

❮ Previous
Next ❯

Software Mentioned

Visual Basic for Applications ( VBA )
- Template
SenseWear
SenseWear Professional
Excel

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.