Inflammatory cytokines prime adipose tissue mesenchymal stem cells to enhance malignancy of MCF-7 breast cancer cells via transforming growth factor-β1

IUBMB Life
Drenka TrivanovićDiana Bugarski

Abstract

Mesenchymal stem cells from human adipose tissue (hASCs) are proposed as suitable tools for soft tissue engineering and reconstruction. Although it is known that hASCs have the ability to home to sites of inflammation and tumor niche, the role of inflammatory cytokines in the hASCs-affected tumor development is not understood. We found that interferon-γ (IFN-γ) and/or tumor necrosis factor-α (TNF-α) prime hASCs to produce soluble factors which enhance MCF-7 cell line malignancy in vitro. IFN-γ and/or TNF-α-primed hASCs produced conditioned media (CM) which induced epithelial to mesenchymal transition (EMT) of MCF-7 cells by reducing E-Cadherin and increasing Vimentin expression. Induced EMT was accompanied by increased invasion, migration, and urokinase type-plasminogen activator (uPA) expression in MCF-7 cells. These effects were mediated by increased expression of transforming growth factor-β1(TGF-β1) in cytokines-primed hASCs, since inhibition of type I TGF-β1 receptor on MCF-7 cells and neutralization of TGF-β1 disabled the CM from primed hASCs to increase EMT, cell migration, and uPA expression in MCF-7 cells. Obtained data suggested that IFN-γ and/or TNF-α primed hASCs might enhance the malignancy of MCF-7 cell line by in...Continue Reading

References

Aug 2, 2005·Nature Reviews. Cancer·Britta WeigeltLaura J van 't Veer
Apr 3, 2007·Trends in Immunology·Antonio UccelliLorenzo Moretta
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Apr 13, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shyam A PatelPranela Rameshwar
Jul 2, 2010·Cold Spring Harbor Perspectives in Biology·Kornelia Polyak, Raghu Kalluri
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jun 28, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·M Raza Zaidi, Glenn Merlino
Jul 30, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jelena KocicJuan F Santibanez
Nov 29, 2011·Cell·Peter Friedl, Stephanie Alexander
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
May 31, 2012·Cancer Letters·Yuan-Yuan WangCatherine Muller
Jun 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Emily M ChandlerClaudia Fischbach
Jun 21, 2012·Cancer Metastasis Reviews·Yvette Drabsch, Peter ten Dijke
Oct 4, 2012·Proceedings of the National Academy of Sciences of the United States of America·Christelle P El-HaibiAntoine E Karnoub
May 11, 2013·International Journal of Cancer. Journal International Du Cancer·Roger A VaughanKristina A Trujillo
Jul 12, 2013·Theranostics·Hyangsoon NohShuang Huang
Aug 21, 2013·Cancer Cell·Tanya Bondar, Ruslan Medzhitov
Aug 31, 2013·Molecular Cancer·Rudi BeyaertFilip De Keyser
Oct 1, 2013·The Breast : Official Journal of the European Society of Mastology·Thordur Oskarsson
Oct 25, 2013·Nature Reviews. Cancer·Eran ElinavRichard A Flavell
Nov 12, 2013·International Journal of Cancer. Journal International Du Cancer·Valentina MeleGiandomenica Iezzi
Feb 8, 2014·Journal of Hematology & Oncology·Zhao SunRobert Chunhua Zhao
Mar 22, 2014·Biomedical Reports·Jian Guan, Jie Chen
Jan 15, 2015·British Journal of Cancer·F BertoliniM G Kolonin
Feb 20, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Anna LaurenzanaGabriella Fibbi
May 12, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·I AcerbiV M Weaver
May 23, 2015·Stem Cells International·Riccardo SchweizerJan A Plock

❮ Previous
Next ❯

Citations

Sep 16, 2016·Mediators of Inflammation·Drenka TrivanovićAleksandra Jauković
May 6, 2017·Stem Cells International·Pedro M Aponte, Andrés Caicedo
Dec 6, 2017·Journal of Biomedical Science·Isela Martínez-RezaRocío García-Becerra
Nov 8, 2018·Cancer Biology & Therapy·Kara McNairTrevor W Stone
Aug 30, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Drenka TrivanovićJuan F Santibanez
Jan 19, 2018·Oncology Letters·Yu WangZhitu Zhu
May 28, 2019·International Journal of Molecular Sciences·Yuhan JiangBo Ma
Nov 10, 2018·Environmental Science and Pollution Research International·Seema Patel, Sushree Sangeeta
Jul 3, 2018·Oncology Letters·Shijian ZhangChenping Zhang
Apr 17, 2021·International Immunopharmacology·Huan-Rong LanXue Yang
Dec 30, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Seema Patel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.