PMID: 3745958Apr 1, 1986Paper

Inflammatory effect of intradermal administration of soluble phospholipase A2 in rabbits

The Journal of Investigative Dermatology
W PruzanskiV Fornasier

Abstract

Extracellular phospholipase A2 (PLA2) has been found in association with inflamed sites in experimental animals and in humans. The tissue effects of soluble PLA2 have not been defined. We studied the development of inflammatory changes in rabbit skin subsequent to intradermal injection of active and inactivated venom and pancreatic PLA2, over a broad concentration range. PLA2, at concentrations encountered in human disease, caused acute inflammatory changes characterized grossly by erythema and induration, and histologically by inflammatory cell infiltration, vascular and tissue damage, and abscess formation. Extracellular PLA2 may be considered as one of the pathogenic factors in inflammatory reaction.

References

Nov 1, 1979·The British Journal of Ophthalmology·A G SecchiF D'Ermo
Dec 1, 1964·The Biochemical Journal·S A IbrahimR H Thompson
Jul 1, 1983·British Medical Bulletin·G J Blackwell, R J Flower
Jun 1, 1983·Canadian Journal of Physiology and Pharmacology·P Vadas, J B Hay
Jan 1, 1980·Scandinavian Journal of Gastroenterology·T J Nevalainen
Nov 15, 1981·The Biochemical Journal·P D WightmanR J Bonney

❮ Previous
Next ❯

Citations

Feb 1, 1993·Arthritis and Rheumatism·J S Bomalaski, M A Clark
Aug 4, 1999·Critical Reviews in Clinical Laboratory Sciences·E Kaiser
Jun 9, 2006·European Journal of Immunology·Francescopaolo GranataMassimo Triggiani
Sep 26, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroTinnakorn Chaiworapongsa
Sep 27, 2018·Drug Development Research·José R AlmeidaSaulo L da Silva
Apr 1, 1989·Annals of the Rheumatic Diseases·H Gonzalez-BuriticaG R Hughes
Apr 15, 1989·European Journal of Biochemistry·J PfeilschifterI Wiesenberg
Jul 4, 1998·The British Journal of Surgery·W UhlM W Büchler
Jan 1, 1991·Scandinavian Journal of Rheumatology·C L YuS R Wang
Dec 26, 2001·European Journal of Immunology·Massimo TriggianiGianni Marone
Jun 20, 2000·Toxicon : Official Journal of the International Society on Toxinology·R C de CastroE Antunes
Sep 25, 1992·Biochemical Pharmacology·W PruzanskiP Vadas
Oct 17, 1989·Biochimica Et Biophysica Acta·M MurakamiK Inoue
Oct 1, 1990·Clinical Biochemistry·E KaiserK Zaky
Nov 30, 1992·Biochemical and Biophysical Research Communications·K M TramposchF I Carroll
Feb 4, 2006·The Journal of Investigative Dermatology·Glynis A ScottAlice P Pentland
Sep 6, 2006·Biochimica Et Biophysica Acta·Massimo TriggianiGianni Marone

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.