Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom: leukocyte recruitment and release of cytokines

Toxicon : Official Journal of the International Society on Toxinology
Cristina Maria FernandesCatarina de Fátima Pereira Teixeira

Abstract

The inflammatory events induced by BaP1, a 22.7 kDa metalloproteinase isolated from Bothrops asper snake venom, were studied. BaP1 i.p. injection in mice induced a marked inflammatory cell infiltrate into peritoneal cavity of animals with predominance of neutrophils in the early phase followed by mononuclear cells in the late period. Inhibition of enzymatic activity of BaP1 by chelation with EDTA resulted in a drastic reduction of this effect. In addition, BaP1 induced a significant increase of blood neutrophil numbers before its accumulation in peritoneal cavity, thus suggesting a stimulatory action of BaP1 on mechanisms of cell mobilization from bone marrow reserve compartments. A reduction in the number of neutrophils was observed in the exudate when antibodies against LECAM-1, CD18 and LFA-1 were used, suggesting the involvement of these adhesion molecules in the effects of BaP1. In contrast, there was no effect with antibodies against ICAM-1 and PECAM-1. Moreover, a conspicuous increment in the levels of IL-1 and TNF-alpha, but not of LTB4, was observed in peritoneal washes collected from mice injected with BaP1. It is concluded that BaP1 induces in vivo a marked leukocyte influx, which parallels an increased number of the...Continue Reading

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Citations

Mar 20, 2013·BioMed Research International·Ji-Fu WeiShaoheng He
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Jan 5, 2010·Toxicon : Official Journal of the International Society on Toxinology·Maung-Maung ThwinPonnampalam Gopalakrishnakone
Sep 24, 2009·Toxicon : Official Journal of the International Society on Toxinology·Catarina TeixeiraFernando Chaves
Apr 28, 2009·Toxicon : Official Journal of the International Society on Toxinology·Ji-Fu WeiShao-Heng He
Mar 31, 2009·Toxicon : Official Journal of the International Society on Toxinology·Catarina TeixeiraFernando Chaves
Mar 17, 2009·Toxicon : Official Journal of the International Society on Toxinology·Daiana Silva LopesVeridiana de Melo Rodrigues
Aug 13, 2009·Toxicon : Official Journal of the International Society on Toxinology·Carolina de Freitas OliveiraVeridiana de Melo Rodrigues
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