Inflammatory fatigue and sickness behaviour - lessons for the diagnosis and management of chronic fatigue syndrome

Journal of Affective Disorders
S V Arnett, I A Clark

Abstract

Persistent and severe fatigue is a common part of the presentation of a diverse range of disease processes. There is a growing body of evidence indicating a common inflammatory pathophysiology underlying many conditions where fatigue is a primary patient concern, including chronic fatigue syndrome. This review explores current models of how inflammatory mediators act on the central nervous system to produce fatigue and sickness behaviour, and the commonality of these processes in conditions as diverse as surgical trauma, infection, various cancers, inflammatory bowel disease, connective tissue diseases and autoimmune diseases. We also discuss evidence indicating chronic fatigue syndrome may have important pathophysiological similarities with cytokine mediated sickness behaviour, and what lessons can be applied from sickness behaviour to chronic fatigue syndrome with regards to the diagnosis and management.

References

Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S KentJ L Vannice
Nov 1, 1992·Environmental Health Perspectives·P A Schulte
Jan 1, 1992·Trends in Pharmacological Sciences·S KentR Dantzer
Mar 1, 1988·Annals of Internal Medicine·G P HolmesS Pahwa
Jan 1, 1985·Comparative Immunology, Microbiology and Infectious Diseases·F RossiP de Togni
Jan 1, 1988·Neuroscience and Biobehavioral Reviews·B L Hart
Jan 1, 1982·Immunological Reviews·T R Cupps, A S Fauci
Mar 1, 1984·The Journal of Clinical Investigation·B M Babior
Dec 1, 1980·Agents and Actions·P C Bragt, I L Bonta
Dec 1, 1994·Environmental Health Perspectives·B M Babior
Jan 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·M Maes
Jan 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R PatarcaM A Fletcher
Mar 14, 1994·Brain Research·L R WatkinsS F Maier
Nov 1, 1996·Clinical Immunology and Immunopathology·W S ShengC C Chao
Apr 1, 1997·The Journal of Analytical Psychology·M SimpsonP Holland
Dec 5, 1998·Canadian Journal of Physiology and Pharmacology·B K PedersenH Bruunsgaard
Sep 7, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J K Chia, L Y Chia
Oct 8, 1999·Trends in Endocrinology and Metabolism : TEM·I J Elenkov, G P Chrousos
Jul 25, 2000·Redox Report : Communications in Free Radical Research·R S RichardsH L Butt
Jun 5, 2001·Life Sciences·B Manuel y KeenoyI De Leeuw
Jan 5, 2002·IUBMB Life·H J Forman, M Torres
Mar 20, 2002·The Journal of Experimental Medicine·Thomas R BernikKevin J Tracey
Jul 3, 2002·Clinical and Diagnostic Laboratory Immunology·Benjamin H NatelsonNicholas M Ponzio
Feb 21, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John K S Chia, Andrew Chia
Mar 18, 2003·Journal of Medicinal Food·Amanpreet SinghShrinivas K Kulkarni

❮ Previous
Next ❯

Citations

Jan 24, 2016·Journal of Crohn's & Colitis·Micol ArtomChristine Norton
Oct 6, 2015·Arthritis Research & Therapy·Karine Louati, Francis Berenbaum
Apr 23, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lesley A GraffCharles N Bernstein
Jun 28, 2015·Human Immunology·Mangalathu S RajeevanElizabeth R Unger
Aug 5, 2018·The Journal of Pharmacology and Experimental Therapeutics·Erifili HatziagelakiTheoharis C Theoharides
Feb 2, 2017·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Brad TinkleHoward Levy
Jun 30, 2019·Journal of Translational Medicine·Tiansong YangTetsuya Asakawa
Feb 7, 2020·Brain, Behavior, and Immunity·Zeynab AlshelhMarco L Loggia
Jan 26, 2021·Frontline Gastroenterology·Shellie Jean RadfordGordon Moran
May 4, 2021·Nursing Research·Suja P DavisMillie D Long
Jul 7, 2021·Alimentary Pharmacology & Therapeutics·Jordan J McGingGordon W Moran

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.