Inflammatory gene polymorphisms and susceptibility to kawasaki disease and its arterial sequelae

Pediatrics
Yiu-Fai CheungYu-Lung Lau

Abstract

We tested the hypothesis that single-nucleotide polymorphisms of inflammatory genes C-reactive protein (CRP) and tumor necrosis factor alpha (TNF-alpha) may exert influence on susceptibility to Kawasaki disease and its arterial sequelae. We analyzed the CRP +1444 C-->T and TNF-alpha -308 G-->A polymorphisms in 167 patients aged 8.9 +/- 4.1 years with a history of Kawasaki disease (73 with and 94 without coronary aneurysms) and 124 healthy control subjects. For patients with Kawasaki disease, we further determined whether these single-nucleotide polymorphisms were associated with coronary aneurysms, carotid arterial stiffening, and intima-media thickness. Genotypic and allelic frequencies of CRP +1444 for T carrier and TNF-alpha -308 for A carrier were significantly higher in patients than in control subjects. The genotypic and allelic distributions did not differ between patients with and those without coronary aneurysms; however, patients with CRP +1444 CT/TT genotype compared with those with a CC genotype and patients with TNF-alpha -308 GA/AA genotype compared with those with a GG genotype had significantly greater carotid arterial stiffness and intima-media thickness. Carriers of both CRP +1444 T allele and TNF-alpha -308 A...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Nov 1, 1996·Circulation·R DhillonJ E Deanfield
Apr 28, 1999·Pediatric Clinics of North America·A H Rowley, S T Shulman
Aug 24, 1999·Pediatrics International : Official Journal of the Japan Pediatric Society·S KamizonoK Itoh
Mar 10, 2001·The American Journal of Pathology·K YasojimaP L McGeer
Oct 12, 2001·Biochemical and Biophysical Research Communications·H W Wang, S F Sui
Oct 27, 2001·Circulation Research·G J Blake, P M Ridker
Jul 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·D J BrullA D Hingorani
Jan 13, 2004·Journal of the American College of Cardiology·Yiu-fai CheungAdolphus K T Chau
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
Aug 5, 2006·The Journal of Pediatrics·Kimiyasu EgamiToyojiro Matsuishi
Dec 14, 2006·JAMA : the Journal of the American Medical Association·Leslie A LangeAlexander P Reiner
Jan 16, 2007·Biochemical Genetics·Ming YanChunhong Wang
Aug 4, 2007·Clinical and Experimental Immunology·W B BreunisT W Kuijpers
Aug 28, 2007·The Journal of Pediatrics·Robert Dalla PozzaHeinrich Netz
Sep 18, 2007·Journal of the American College of Cardiology·Fadi G Hage, Alexander J Szalai

❮ Previous
Next ❯

Citations

Apr 23, 2013·The Journal of Infection·Nicola PrincipiSusanna Esposito
Sep 6, 2011·Acta Pharmacologica Sinica·Ho-chang Kuo, Wei-chiao Chang
Dec 23, 2008·Cardiovascular Research·Patrick LacolleyVeronique Regnault
Jan 5, 2010·Human Molecular Genetics·Hsin ChiYann-Jinn Lee
Nov 5, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Ken-Pen WengLuo-Ping Ger
Mar 28, 2013·Computational and Mathematical Methods in Medicine·Yu-wen LvHai-tao Lv
Jan 23, 2009·Journal of Human Genetics·Akira Hata, Yoshihiro Onouchi
May 5, 2009·Current Opinion in Rheumatology·Despina EleftheriouPaul A Brogan
Jul 10, 2010·Current Opinion in Rheumatology·Rae S M Yeung
Nov 21, 2008·European Journal of Pediatrics·Ken YoshimuraKazunari Kaneko
Nov 22, 2011·Archives of Medical Research·Francisco Cruz-OlivoJavier Mancilla-Ramírez
Oct 27, 2009·Best Practice & Research. Clinical Rheumatology·Seza Ozen, Robert C Fuhlbrigge
May 29, 2012·Pediatrics International : Official Journal of the Japan Pediatric Society·Nita ChahalBrian W McCrindle
Feb 2, 2010·Pediatrics International : Official Journal of the Japan Pediatric Society·Yahui T LinBrian W McCrindle
Mar 6, 2010·Pediatrics International : Official Journal of the Japan Pediatric Society·Sakda Arj-OngJohn Attia
Jul 23, 2013·International Journal of Immunogenetics·Elisa MaggioliMariaclara Cuccia
Dec 5, 2014·Journal of Cardiovascular Translational Research·Jeongok G LoganHyungsuk Kim
Feb 15, 2013·Korean Circulation Journal·Mi Hyun KimHae Yong Lee
Mar 27, 2010·Korean Circulation Journal·Ki-Won KimHae Yong Lee
Jul 23, 2011·Korean Circulation Journal·Hye Mi AhnYoung Mi Hong
Apr 28, 2010·Korean Circulation Journal·Yiu-Fai Cheung
May 11, 2010·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Yoshihiro Onouchi
Feb 5, 2009·Pediatric Research·Yoshihiro Onouchi
Jul 3, 2019·Frontiers in Immunology·Stephanie MenikouMichael Levin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.