Inflammatory hypothesis as a link between Alzheimer's disease and diabetes mellitus

Geriatrics & Gerontology International
Melda BozluolcayDildar Konukoglu

Abstract

The aim of the present study was to evaluate whether there was an inflammation-mediated link between Alzheimer's disease (AD) and type 2 diabetes mellitus (DM) status. An age-matched control group and patient groups designated as AD without treatment (AD); AD under cholinesterase inhibitors (AD-CEI); DM without treatment (DM); DM under oral antidiabetic agents (DM-OAD); AD under treatment, who had newly diagnosed DM (AD-CEI+DM); and DM under treatment, who had newly diagnosed probable AD (DM-OAD+AD) were studied. Serum inflammation status was evaluated by the determination of serum C-reactive protein (CRP), tumor necrosis factor-alpha, interleukin (IL)-1β and IL-6 levels. CRP levels were determined by an immunonephelometric method. The others were assayed by enzyme-linked immunosorbent assay methods. IL-1β levels were found to be significantly lower in the DM group than in the control group (P < 0.01). The AD group had significantly higher serum IL-1β levels than the DM group (P < 0.01). IL-6 levels were significantly higher in the AD and DM groups than in controls (P < 0.01 and P < 0.01). Serum tumor necrosis factor-alpha and CRP levels in the AD (P < 0.05 and P < 0.001, respectively) and DM groups (P < 0.05 and P < 0.001, res...Continue Reading

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J RogersP Ward
Dec 1, 1990·Cellular and Molecular Neurobiology·R J DonnellyM P Vitek
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W S GriffinC Araoz
Jan 1, 1995·Neurology·J B RichJ Brandt
Sep 5, 2002·Annals of Neurology·Reinhold SchmidtLenore J Launer
Oct 9, 2003·American Journal of Physiology. Endocrinology and Metabolism·Rikke Krogh-MadsenBente Klarlund Pedersen
Jul 24, 2004·Current Drug Targets·Mathias CacquevelDenis Vivien
Oct 26, 2005·Biochemical Society Transactions·G J BiesselsUNKNOWN Utrecht Diabetic Encephalopathy Study Group
Aug 18, 2006·Journal of Alzheimer's Disease : JAD·Patrick L McGeerEdith G McGeer
Nov 14, 2006·Lipids in Health and Disease·Gumpeny Ramachandra SridharCh Divakar
May 12, 2007·Journal of the American Geriatrics Society·Miranda T SchramRudi G J Westendorp
Nov 30, 2007·Clinical Interventions in Aging·Carolyn W Zhu, Mary Sano
Nov 13, 2008·Archives of Neurology·Howard Jay AizensteinWilliam E Klunk
Nov 28, 2008·Clinical Neurology and Neurosurgery·Francesco RoselliPaolo Livrea
Jan 14, 2009·Archives of Neurology·Joshua A SonnenSuzanne Craft
Oct 20, 2009·Journal of the Neurological Sciences·Massimiliano PlastinoDomenico Bosco
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Weiping Han, Cai Li
Sep 18, 2014·CNS & Neurological Disorders Drug Targets·Ada M TataMarcella Reale
Jun 13, 2015·World Journal of Diabetes·Gumpeny R SridharGumpeny Nagamani

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Citations

Oct 19, 2017·Molecular Neurobiology·T N C MagalhãesMarcio L F Balthazar
Dec 17, 2015·Geriatrics & Gerontology International·Naoki SajiTakashi Sakurai
Aug 15, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·T P KliushnikA M Dupin
May 1, 2020·International Immunopharmacology·Md Sahab UddinGhulam Md Ashraf
May 26, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Urati AnuradhaRakesh Kumar Singh

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