PMID: 2120384Oct 1, 1990Paper

Inflammatory lipid mediator generation elicited by viable hemolysin-forming Escherichia coli in lung vasculature

The Journal of Experimental Medicine
F GrimmingerW Seeger

Abstract

Escherichia coli hemolysin, a transmembrane pore-forming exotoxin, is considered an important virulence factor for E. coli-related extraintestinal infections and sepsis. The possible significance of hemolysin liberation for induction of inflammatory lipid mediators was investigated in isolated rabbit lungs infused with viable bacteria (concentration range, 10(4)-10(7)/ml). Hemolysin-secreting E. coli (E. coli-Hly+), but not an E. coli strain that releases an inactive form of the exotoxin, induced marked lung leukotriene (LT) generation with predominance of cysteinyl LTs. Eicosanoid synthesis was not inhibited in the presence of plasma with toxin-neutralizing capacity. Pre-application of 2 x 10(8) human granulocytes, which sequestered in the lung microvasculature, caused a severalfold increase in leukotriene generation in response to E. coli-Hly+ challenge both in the absence and presence of plasma. Data are presented indicating neutrophil-endothelial cell cooperation in arachidonic acid lipoxygenase metabolism as an underlying mechanism. We conclude that liberation of hemolysin from viable E. coli induces marked lipid mediator generation in lung vasculature, which is potentiated in the presence of neutrophil sequestration and m...Continue Reading

References

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Citations

Jan 1, 1994·Molecular Aspects of Medicine·G MenestrinaC Montecucco
May 1, 1996·Veterinary Microbiology·P G FunkM M Chengappa
Oct 1, 1994·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·C R ClarkeJ H Wyckoff
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·L KissF Grimminger
Jul 17, 2009·Clinical and Experimental Immunology·S AnwarI Sabroe
Mar 6, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Antonio Di GennaroAngelo Sala
Jul 26, 1996·The Journal of Biological Chemistry·A SalaG Folco
Apr 5, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Thomas A RussoPaul R Knight
Feb 12, 1998·The Journal of Biological Chemistry·I V RybinaS J Feinmark

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