Inflammatory Marker Testing Identifies CD74 Expression in Melanoma Tumor Cells, and Its Expression Associates with Favorable Survival for Stage III Melanoma

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Suhendan EkmekciogluElizabeth A Grimm

Abstract

Inflammatory marker expression in stage III melanoma tumors was evaluated for association with outcome, using two independent cohorts of stage III melanoma patients' tumor tissues. Fifteen markers of interest were selected for analysis, and their expression in melanoma tissues was determined by immunohistochemistry. Proteins associating with either overall survival (OS) or recurrence-free survival (RFS) in the retrospective discovery tissue microarray (TMA; n = 158) were subsequently evaluated in an independent validation TMA (n = 114). Cox proportional hazards regression models were used to assess the association between survival parameters and covariates, the Kaplan-Meier method to estimate the distribution of survival, and the log-rank test to compare distributions. Expression of CD74 on melanoma cells was unique, and in the discovery TMA, it associated with favorable patient outcome (OS: HR, 0.53; P = 0.01 and RFS: HR, 0.56; P = 0.01). The validation data set confirmed the CD74 prognostic significance and revealed that the absence of macrophage migration inhibitory factor (MIF) and inducible nitric oxide synthase (iNOS) was also associated with poor survival parameters. Consistent with the protein observation, tumor CD74 mR...Continue Reading

References

Apr 29, 1998·Journal of the National Cancer Institute·O GalloM Ziche
Jun 5, 2003·The Journal of Experimental Medicine·Lin LengRichard Bucala
Aug 18, 2005·Journal of the National Cancer Institute·Lisa M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Mar 25, 2006·International Journal of Cancer. Journal International Du Cancer·Suhendan EkmekciogluElizabeth A Grimm
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Victor G PrietoMenashe Bar-Eli
Nov 29, 2008·Cancer Immunology, Immunotherapy : CII·C Christian JohanssonRolf Kiessling
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Jun 18, 2009·World Journal of Gastroenterology : WJG·Ellen J Beswick, Victor E Reyes
Nov 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Dusan BogunovicNina Bhardwaj
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M BalchVernon K Sondak
Dec 4, 2009·Carcinogenesis·Aaron J SchetterCurtis C Harris
Apr 7, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M BalchVernon K Sondak
Jan 7, 2011·Expert Opinion on Therapeutic Targets·Federica Borghese, Felix I L Clanchy
Mar 18, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Huapeng FanMichael J Hickey
Sep 29, 2011·Molecular Cancer Research : MCR·Yong QinElizabeth A Grimm
Feb 7, 2012·Nature Immunology·Genc BashaWilfred A Jefferies
Aug 9, 2012·Theory in Biosciences = Theorie in Den Biowissenschaften·Günter P WagnerVincent J Lynch
Aug 15, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ioannis KarakikesNelson Fernandez
Mar 1, 2013·Proceedings of the National Academy of Sciences of the United States of America·Rizwan HaqDavid E Fisher
Jul 23, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elizabeth A GrimmSuhendan Ekmekcioglu
Mar 7, 2014·British Journal of Cancer·C OtterstromV Serre-Beinier
Feb 26, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sofia LourencoSam M Janes
Apr 8, 2015·Breast Cancer Research : BCR·Sergio Granados-PrincipalJenny C Chang
Jun 4, 2015·The Journal of Investigative Dermatology·Keiji TaneseElizabeth A Grimm

❮ Previous
Next ❯

Citations

Oct 28, 2019·Oncoimmunology·Daniëlle VerverAlexander M M Eggermont
Apr 5, 2018·Frontiers in Oncology·Sun-Hee KimSuhendan Ekmekcioglu
Apr 25, 2019·Cancers·Laura SoumoyFabrice Journe
Aug 8, 2018·Disease Models & Mechanisms·Rom Keshet, Ayelet Erez
May 1, 2021·International Journal of Molecular Sciences·Luca TonellaPietro Quaglino
Jul 10, 2021·Nature Medicine·Miles C AndrewsJennifer A Wargo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Guo-Hui SunJing Yang
International Journal of Clinical and Experimental Pathology
Wen LiuLijun Tian
© 2022 Meta ULC. All rights reserved