Inflammatory markers associated with seizures

Epileptic Disorders : International Epilepsy Journal with Videotape
Hong Seok SohnSeo-Young Lee

Abstract

Seizures can produce systemic changes, including elevated body temperature, white blood cell count, and C-reactive protein levels, which raises concern for potential infection. We describe seizure-induced inflammation-like responses and discuss how these changes may be distinguished from those associated with infection. We prospectively investigated 140 consecutive visits to the emergency room, in which patients presented with seizures. We defined elevated body temperature, white blood cell count, or C-reactive protein levels as inflammation-like responses. We investigated the occurrence of inflammation-like responses, characteristics of the seizures, neurological status at the initial visit, outcomes, and clinical findings to determine the presence of infection. We ascertained whether the patients had infection or not based on the overall information post-discharge. An inflammation-like response was observed in 56.3% of all visits and 19.3% were diagnosed with concurrent infection. Among the visits with inflammation-like response, 34.7% were shown to have an infection. Increases in body temperature and C-reactive protein levels were milder (<39°C and <6 mg/dl, respectively) in patients without infection compared to those with ...Continue Reading

Citations

Feb 27, 2019·Journal of Neurology·Sebastian StösserHermann Neugebauer
Apr 3, 2020·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Shimon IzhakianMordechai R Kramer
Apr 16, 2020·Revista gaúcha de enfermagem·Edson Fernando Muller GuzzoMárcia Koja Breigeiron
Jul 18, 2019·Frontiers in Neurology·Dominik KobylarekWojciech Kozubski
Nov 24, 2020·Curēus·Taranjeet S JollyRaman Baweja

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