PMID: 8949969Oct 1, 1996Paper

Inflammatory markers in childhood asthma

Annals of Medicine
S KristjánssonG Wennergren

Abstract

The importance of airway inflammation in the pathogenesis of asthma is clearly established. Studies in adults as well as in children have led to the concept that asthma is a chronic inflammatory disease. Airway inflammation is found even in mild asthma. Bronchoconstriction and hyper-reactivity appear to be secondary to the release of inflammatory mediators. The changed view of the pathogenesis of asthma and current emphasis on anti-inflammatory treatment have raised a need for markers that reflect the inflammatory status in the airways. This is of special importance in paediatric practice because lung function tests are less easily performed in young children, and it is preferable to keep steroid doses as low as possible. The eosinophil granulocyte has a multitude of proinflammatory functions and plays a key role in the asthmatic inflammation. It secretes toxic proteins and produces cytokines, which have important roles in airway inflammation. Use of eosinophil granula proteins to monitor inflammation is now finding its place. Measurement of eosinophil cationic protein (ECP) seems to be a valuable complement to the recording of lung function. For paediatric use, measurement of urinary eosinophil protein X (EPX) is promising bec...Continue Reading

References

May 29, 1975·The New England Journal of Medicine·B R HornA Van Kessel
Jan 1, 1991·The Journal of Allergy and Clinical Immunology·M CarlsonP Venge
Jan 1, 1991·The Journal of Allergy and Clinical Immunology·H KitaG J Gleich
Oct 11, 1990·The New England Journal of Medicine·J BousquetP Godard
Dec 1, 1989·The Journal of Allergy and Clinical Immunology·S R DurhamA B Kay
Mar 1, 1989·The American Review of Respiratory Disease·S MotojimaG J Gleich
Mar 1, 1989·The American Review of Respiratory Disease·R BeasleyS T Holgate
Jul 1, 1987·The American Review of Respiratory Disease·L M FabbriC E Mapp
May 1, 1988·European Journal of Haematology·C G PetersonP Venge
Jul 1, 1988·The American Review of Respiratory Disease·K R Patel, E Peers
Dec 1, 1988·The American Review of Respiratory Disease·P VengeC G Peterson
Nov 1, 1982·The Journal of Allergy and Clinical Immunology·K FredensP Venge
Jul 1, 1995·American Journal of Respiratory and Critical Care Medicine·W W BusseL J Rosenwasser
Jul 1, 1995·American Journal of Respiratory and Critical Care Medicine·J V FahyH A Boushey
Nov 1, 1994·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·S KristjánssonG Wennergren
Nov 1, 1994·Annals of Internal Medicine·W R Henderson
May 1, 1994·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·E A Colocho ZelayaO Strannegård
Jan 1, 1994·Allergy·P Venge
Oct 1, 1993·The American Review of Respiratory Disease·P J Barnes, S Pedersen
Jul 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B ZimmermanS Ahlstedt
Nov 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D S RobinsonA B Kay
Jun 1, 1996·The Journal of Allergy and Clinical Immunology·S KristjánssonG Wennergren
Jan 1, 1991·The Journal of Automatic Chemistry·M E Ferriter

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Citations

Apr 18, 2006·The Journal of Pediatrics·Erwin W GelfandMichael E Ruff
Oct 16, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K Storm van's GravesandeJ Kuehr
Mar 27, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A NiimiF Kuze

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