Inflammatory markers in human follicular fluid correlate with lipid levels and Body Mass Index

Journal of Reproductive Immunology
Macarena B GonzalezRebecca L Robker

Abstract

The detrimental consequences of obesity on female fertility are well known, but the functional changes that occur in the ovary in response to elevated BMI are not clear. Obesity induces multiple components of a systemic inflammatory state that is a key pathway by which it initiates tissue dysfunction in adipose, liver and muscle; however whether obesity induces similar inflammatory changes in the ovary has not been fully investigated. This is important to understand because it is increasingly clear that obesity at conception impacts not only pregnancy rates but also influences pre-implantation embryo development. To further understand the characteristics of inflammation in the ovaries of obese women we analysed a panel of cytokines (IL6, IL10 and TNFα), adipokines (adiponectin, leptin and monocyte chemotactic factor 1 (MCP-1)) and acute phase proteins (C-Reactive Protein (CRP) and sICAM-1) in the ovarian follicular fluid obtained at oocyte aspiration from women (n = 48) who were lean, overweight or obese. We hypothesised that adipokines and pro-inflammatory cytokines would be correlated with and/or dysregulated by increasing Body Mass Index (BMI). Surprisingly however, the majority were not related to BMI but instead were posit...Continue Reading

Citations

Feb 2, 2019·The Journal of Endocrinology·Miguel A VelazquezAdam J Watkins
Oct 19, 2019·Pediatric Research·Selma Feldman WitchelAlexia S Peña
Jun 21, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alaa ShehadehArieh Moussaieff
Nov 22, 2019·Frontiers in Cell and Developmental Biology·Zhenghong ZhangYan Zhang
Nov 17, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xin ZengZhong-Cheng Mo
Feb 13, 2021·International Journal of Molecular Sciences·Francesca ParisiIrene Cetin
May 22, 2021·Reproductive Biology and Endocrinology : RB&E·Chenchen SiZhide Ding
Jul 1, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xin SuBin Wang
Sep 4, 2021·Reproductive Biomedicine Online·Brandon A WyseClifford Librach
Dec 18, 2021·Biology of Reproduction·Macarena B GonzalezRyan D Rose
Feb 2, 2022·Epidemiology·Anne Marie Z JukicAnne Z Steiner

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