Inflammatory mediators in a short-time mouse model of doxorubicin-induced cardiotoxicity

Toxicology and Applied Pharmacology
Michela PecoraroAda Popolo

Abstract

Doxorubicin (DOXO) is commonly used to treat a wide range of malignant tumors, but its clinical use is limited by acute and chronic cardiotoxicity. The precise mechanism underlying DOXO-induced cardiotoxicity is still not completely elucidated, but cardiac inflammation seems to be involved. Effects of DOXO on proinflammatory cytokines, inflammatory cell infiltration, and necrosis have been proven only when a functional impairment has already occurred, so this study aimed to investigate the acute effect of DOXO administration in mouse heart. The results of our study demonstrated alterations in cardiac function parameters assessed by ultrasound within 24h after a single injection of DOXO, with a cumulative effect along the increase of the dose and the number of DOXO administrations. At the same time, DOXO causes a significant production of proinflammatory cytokines (such as TNF-α and IL-6) with a concomitant reduction of IL-10, a well-known antiinflammatory cytokine. Furthermore, overexpression of inducible nitric oxide synthase (iNOS) in heart tissue and increased levels of serum nitrite in DOXO-treated mice were detected. Notably, DOXO administration significantly increased nitrotyrosine expression in mouse heart. Our data supp...Continue Reading

References

Apr 15, 1997·The American Journal of Cardiology·G A MacGowanS Murali
Mar 15, 2000·Journal of the American College of Cardiology·A M FeldmanC McTiernan
Oct 29, 2000·Annals of the Rheumatic Diseases·B Bozkurt
Jan 3, 2001·The Journal of Clinical Investigation·P P Tak, G S Firestein
May 30, 2003·Pharmacological Reviews·K AsadullahH D Volk
Apr 20, 2004·Japanese Heart Journal·Tsugiyasu Kanda, Takashi Takahashi
Aug 10, 2005·European Journal of Heart Failure·Mamoru SatohKatsuhiko Hiramori
Oct 30, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Ei IkegamiShunichi Ogawa
Jan 17, 2009·Cancer Research·Alexander RiadCarsten Tschöpe
Aug 24, 2010·Progress in Cardiovascular Diseases·Daniela Cardinale, Maria Teresa Sandri
Oct 18, 2011·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jinzhou ZhuWei Han
Nov 15, 2011·Clinical and Experimental Medicine·Tarek A Abd El-AzizHisham R Abdel-Aziz
Apr 3, 2012·Journal of Molecular and Cellular Cardiology·Yanti OctaviaAn L Moens
Jun 16, 2012·Cardiology·Lars GullestadPål Aukrust
Feb 27, 2013·Free Radical Research·A PopoloS Marzocco
Mar 6, 2013·Journal of Cancer Science & Therapy·Maira S OliveiraMarilia M Melo
Oct 8, 2013·PloS One·Simona AdessoStefania Marzocco
Dec 21, 2013·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Runmin GuoJianqiang Feng
Jun 25, 2014·OncoTargets and Therapy·Dinesh VyasArpitak K Vyas
Jul 9, 2014·Archivos de cardiología de México·Joel Salazar-MendiguchíaAngel Cequier
Apr 15, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Bertha Furlan PolegatoLuiz Shiguero Matsubara
Apr 18, 2015·Toxicology and Applied Pharmacology·Marisanta Del RegnoStefania Marzocco
Aug 1, 2015·Journal of Cardiovascular Translational Research·Daniela SorrientoMichele Ciccarelli

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Citations

Jul 12, 2017·Dose-response : a Publication of International Hormesis Society·Saeed SamarghandianMohsen Azimi-Nezhad
Oct 12, 2017·International Journal of Molecular Sciences·Michela PecoraroAda Popolo
Mar 10, 2018·International Journal of Molecular Sciences·Michela PecoraroAda Popolo
Aug 9, 2017·Cancer Chemotherapy and Pharmacology·Mohamed M Abdel-DaimAmal A M Ahmed
Feb 23, 2020·International Journal of Molecular Sciences·Marianne K O GrantBeshay N Zordoky
Jan 10, 2020·Cancer Chemotherapy and Pharmacology·Mohammad SheibaniAhmad Reza Dehpour
Nov 30, 2016·Journal of Cachexia, Sarcopenia and Muscle·Sheng-Chih HuangChia-Hua Kuo
Jun 18, 2017·Cardiovascular Toxicology·Mehdi Ahmadian, Valiollah Dabidi Roshan
Nov 23, 2017·Cancer Causes & Control : CCC·Efthymios Papadopoulos, Daniel Santa Mina
Nov 21, 2019·BMC Complementary and Alternative Medicine·Sheng ZhangYan-Fei Xin
Oct 8, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·N MartínezM C Crespo
Jan 13, 2017·Biology of Sex Differences·Marianne K O GrantBeshay N Zordoky
Dec 13, 2017·International Journal of Molecular Sciences·Simona SeriniGabriella Calviello
Sep 25, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Sushma HavanurNitesh Kumar
Oct 16, 2020·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Xiaoxing ZhangSong Xiao
Feb 7, 2021·Life Sciences·Ankush Kumar JhaBidya Dhar Sahu
Jul 30, 2021·Environmental Science and Pollution Research International·Sara Asaad Abdulkareem AljumailyEyup Altinoz
Aug 28, 2021·International Journal of Molecular Sciences·Ibrahim Y AbdelgawadBeshay N Zordoky
Jan 4, 2022·Journal of Biomedical Nanotechnology·Yumei QianLingling Shan

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