Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review

Mediators of Inflammation
D C B CortelaE Ignotti

Abstract

Reactional episodes in leprosy are a result of complex interactions between the immune system, Mycobacterium leprae, and predisposing factors, including dental infections. To determine the main inflammatory mediators in the immunopathological process of dental infections and leprosy reactions, we conducted a systematic review of primary literature published between 1996 and 2013. A three-stage literature search was performed (Stage I, "leprosy reactions" and "inflammatory mediators"; Stage II, "dental infections" and "inflammatory mediators"; and Stage III, "leprosy reactions," "dental infections," and "inflammatory mediators"). Of the 911 eligible publications, 10 were selected in Stage I, 68 in Stage II, and 1 in Stage III. Of the 27 studied inflammatory mediators, the main proinflammatory mediators were IL-6, IFN-γ, TNF-α, IL-1β, and IL-17; the main anti-inflammatory mediators were IL-10 and IL-4. Serum IL-6 and TNF-α concentrations were significant during periodontal and reactional lesion evolution; IFN-γ and IL-1β were associated with types 1 and 2 reactions and chronic periodontal disease. The proinflammatory mediators in dental infections and leprosy reactions, especially IL-6 and TNF-α, were similar across studies, rega...Continue Reading

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Citations

Sep 30, 2016·International Dental Journal·Yue GuoHou-De Zhou
Sep 9, 2016·Oral Diseases·G A RodriguesAcf Motta
Oct 21, 2016·Memórias do Instituto Oswaldo Cruz·Maria Renata Sales NogueiraMaria Esther Salles Nogueira
Nov 15, 2018·Revista Do Instituto De Medicina Tropical De São Paulo·Denise Costa Boamorte CortelaEliane Ignotti
Jul 18, 2021·BMC Oral Health·Simone G OliveiraFlavio H B Aguiar

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Methods Mentioned

BETA
ELISA
biopsy
biopsies

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