Inflammatory mediators potentiate high affinity GABA(A) currents in rat dorsal root ganglion neurons.

Neuroscience Letters
Kwan Yeop Lee, M S Gold

Abstract

Following acute tissue injury action potentials may be initiated in afferent processes terminating in the dorsal horn of the spinal cord that are propagated back out to the periphery, a process referred to as a dorsal root reflex (DRR). The DRR is dependent on the activation of GABA(A) receptors. The prevailing hypothesis is that DRR is due to a depolarizing shift in the chloride equilibrium potential (E(Cl)) following an injury-induced activation of the Na(+)-K(+)-Cl(-)-cotransporter. Because inflammatory mediators (IM), such as prostaglandin E(2) are also released in the spinal cord following tissue injury, as well as evidence that E(Cl) is already depolarized in primary afferents, an alternative hypothesis is that an IM-induced increase in GABA(A) receptor mediated current (I(GABA)) could underlie the injury-induced increase in DRR. To test this hypothesis, we explored the impact of IM (prostaglandin E(2) (1 μM), bradykinin (10 μM), and histamine (1 μM)) on I(GABA) in dissociated rat dorsal root ganglion (DRG) neurons with standard whole cell patch clamp techniques. IM potentiated I(GABA) in a subpopulation of medium to large diameter capsaicin insensitive DRG neurons. This effect was dependent on the concentration of GABA, ...Continue Reading

References

Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·A Feigenspan, J Bormann
Mar 25, 1999·Experimental Brain Research·W D Willis
Nov 7, 1999·Experimental Brain Research·P Rudomin, R F Schmidt
Jun 25, 2003·European Journal of Pain : EJP·Fernando CerveroEsther García-Nicas
Oct 1, 1963·The Journal of Physiology·J C ECCLESW D WILLIS
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Brandon M StellIstvan Mody
Mar 2, 2005·Nature Reviews. Neuroscience·Mark Farrant, Zoltan Nusser
May 20, 2006·Journal of Neurophysiology·Sandra Valencia-de ItaWilliam D Willis
Sep 2, 2006·The Journal of Physiology·Shao-Gang LuMichael S Gold
Feb 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Josef T KittlerStephen J Moss
Apr 4, 2008·Journal of Neurophysiology·Héctor I Rocha-GonzálezFrancisco J Alvarez-Leefmans
May 10, 2008·The Journal of Pain : Official Journal of the American Pain Society·Vanessa C Z Anseloni, Michael S Gold
Jan 27, 2009·Brain Research Reviews·Theodore J PriceSteven A Prescott
Jun 11, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrea H Vaughn, Michael S Gold
Oct 14, 2010·The Journal of Biological Chemistry·Armen M AbramianStephen J Moss
Oct 1, 2002·Neuromodulation : Journal of the International Neuromodulation Society·David W Garrison, Robert D Foreman

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Citations

Apr 15, 2014·European Journal of Pharmacology·Mariana Bravo-HernándezHéctor Isaac Rocha-González
Sep 27, 2014·Neuroscience·D Guo, J Hu
Dec 3, 2016·The Journal of Pain : Official Journal of the American Pain Society·C Richard Chapman, Charles J Vierck
Apr 4, 2015·Cell Transplantation·Priscilla D NegraesHenning Ulrich
Aug 24, 2013·Journal of Neurophysiology·Emanuel Loeza-AlcocerRodolfo Delgado-Lezama
Aug 14, 2021·Frontiers in Pharmacology·Caixue WangXiaona Du

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