Inflammatory myofibroblastic tumor of bone: two cases occurring in long bone.

Skeletal Radiology
Jianyu ChenYebin Jiang

Abstract

Inflammatory myofibroblastic tumor (IMT) is an unusual tumor composed of differentiated myofibroblastic spindle cells usually accompanied by numerous plasma cells and lymphocytes. IMT was originally described in the lung; occurrence in a long bone is rare. We present two examples of IMT arising in a long bone: one in the humerus and one in the femur. In both cases, imaging shows a poorly delineated osteolytic lesion with cortical bone destruction that aggressively extends into surrounding soft tissue. Histologically, the lesion is dominated by differentiated spindle cells with aprominent collagenous stroma and an inflammatory component including plasma cells and lymphocytes, and with positive immunoreactivity for anaplastic lymphoma kinase. The absence of cytologic atypia helps differentiate this lesion from malignant spindle cell tumors.

References

Dec 1, 1991·The American Journal of Surgical Pathology·J M Meis, F M Enzinger
Apr 1, 1995·The Annals of Otology, Rhinology, and Laryngology·J G BatsakisH Goepfert
Feb 1, 1994·Human Pathology·L LundgrenL G Kindblom
Oct 23, 1997·The American Journal of Surgical Pathology·R SciotH Van den Berghe
Aug 10, 2000·The American Journal of Pathology·B LawrenceJ A Fletcher
Oct 18, 2000·Archives of Pathology & Laboratory Medicine·K WatanabeT Suzuki
Jun 15, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·C M CoffinC A Griffin
Dec 4, 2003·Rheumatology International·Y AllanoreA Kahan
Dec 4, 2004·The American Journal of Surgical Pathology·Toyonori TsuzukiJonathan I Epstein
Dec 23, 2008·The Journal of Craniofacial Surgery·Jung-Hwan OhYong-Dae Kwon

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