Inflammatory myofibroblastic tumor of the lung

Advances in Respiratory Medicine
Akshay KhatriNikhil Meena

Abstract

Inflammatory myofibroblastic tumors (IMT) of the lung, first reported in 1939, are considered a subset of inflammatory pseudo -tumors. They are a distinctive lesions composed of myofibroblastic spindle cells accompanied by an inflammatory infiltrate of plasma cells, lymphocytes, and eosinophils. IMTs may be benign, invade surrounding structures, undergo malignant transformation, recur or may even metastasize. They can occur due to a genetic mutation or can occur secondary to infectious or autoimmune diseases. Patients may be asymptomatic, or present with cough, hemoptysis, dyspnea, pleuritic pain, constitutional symptoms or pneumonia. In this article we review the pathophysiology, genetics, clinical presentation, imaging findings of IMT of the lung. We also discuss the various surgical and non-surgical treatment options and the prognosis associated with this disease.

Citations

Feb 28, 2019·Case Reports in Otolaryngology·Hind K AlshammariHaitham Kussaibi
Dec 19, 2018·Medicine·Bingxue ChengLi Zhou
Aug 29, 2020·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Matteo PonzoniMassimo A Padalino
Dec 1, 2020·Respiratory Medicine Case Reports·Merian E KuipersBart P C Hoppe
Jun 22, 2021·Journal of Bronchology & Interventional Pulmonology·Mohammad Abu-HishmehOleg Epelbaum
Jul 16, 2021·Anti-cancer Drugs·Haluk Cihad AlbayrakAhmet Özet

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