PMID: 9537467Apr 16, 1998Paper

Inflammatory myofibroblastic tumor of the pancreaticobiliary region: morphologic and immunocytochemical study of three cases

The American Journal of Surgical Pathology
S V WalshU Khettry

Abstract

Inflammatory myofibroblastic tumor (IMT) is a rare tumor of the pancreaticobiliary region. The etiology and biologic behavior of IMTs at this site are unknown. We present three patients with IMT of the pancreaticobiliary region, each with long-term follow-up. In all three cases a second tumor developed. Grossly these tumors mimicked a malignant process. Microscopically, all were composed of an admixture of spindle cells and chronic inflammatory cells, including plasma cells, lymphocytes, eosinophils, and macrophages. The spindle cells stained positively for smooth muscle actin and vimentin but were negative for S-100, cytokeratin, CD35, and latent membrane protein. Results of in situ hybridization with EBER probes were negative in all cases. In addition to carcinoma, the differential diagnosis of these tumors includes follicular dendritic cell tumor and inflammatory fibrosarcoma. The importance of extensive pathologic examination to prevent misdiagnosis and the need for long-term follow-up are emphasized. This subset of IMT does not appear to be related to Epstein-Barr virus.

References

Apr 1, 1979·The British Journal of Surgery·J D StamatakisR Williams
Oct 1, 1978·The Journal of Pediatrics·P T PisciottoD R Miller
Aug 1, 1988·Journal of Pediatric Surgery·L ScottG Fraser
Jan 1, 1973·Cancer·M Bahadori, A A Liebow
Nov 1, 1984·Histopathology·H Spencer
Sep 1, 1983·The American Journal of Surgical Pathology·F Gonzalez-CrussiC Sotelo-Avila
Oct 1, 1995·Human Pathology·D A ArberL M Weiss
Nov 1, 1993·Histopathology·J P Palazzo, C D Chang
May 1, 1993·The American Journal of Surgical Pathology·L R Bégin
Jun 1, 1993·AJR. American Journal of Roentgenology·K M Dudiak

❮ Previous
Next ❯

Citations

Mar 27, 2003·The American Journal of Surgical Pathology·Rhonda K YantissAndrew E Rosenberg
Jun 29, 2006·World Journal of Gastroenterology : WJG·E M Lopez-Tomassetti FernandezA Carrillo Pallares
May 1, 2010·The American Journal of Surgical Pathology·David R LucasJonathan B McHugh
Nov 2, 2004·Virchows Archiv : an International Journal of Pathology·Giuseppe ZamboniGünter Klöppel
Dec 17, 2016·Clinical Case Reports·Muharrem BattalOzgur Bostanci
Mar 3, 2004·Pathology International·Liron PantanowitzImad Nasser
Feb 27, 2003·The American Journal of Surgical Pathology·Susan C AbrahamRalph H Hruban
Dec 14, 2004·Der Pathologe·U PauserG Klöppel
Nov 24, 2006·The American Journal of Surgical Pathology·Vikram DeshpandeGregory Y Lauwers
Aug 27, 2005·Archives of Pathology & Laboratory Medicine·Vikram DeshpandeGregory Y Lauwers
Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Josefine Heim-Hall, Sophia L Yohe
Mar 6, 2009·Archives of Pathology & Laboratory Medicine·Giuseppe ZamboniGünter Klöppel
Jan 11, 2001·Archives of Pathology & Laboratory Medicine·G NesiA Amorosi
May 31, 2006·Gastrointestinal Endoscopy·Anuradha SekaranDuvvuru Nageshwar Reddy
Aug 31, 2006·Seminars in Diagnostic Pathology·N Volkan AdsayDuangpen Thirabanjasak
Aug 27, 2021·World Journal of Clinical Cases·Zhi-Tao ChenSheng-Zhang Lin
Dec 16, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Antonio Martín MalagónHermogenes Díaz Luis
Mar 7, 2009·Clinical Radiology·M W AshcroftA H Freeman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Vojnosanitetski pregled. Military-medical and pharmaceutical review
Zaklina MijovićMilos Kostov
© 2022 Meta ULC. All rights reserved