Inflammatory myofibroblastic tumors of the head and neck: evaluation of clinicopathologic and prognostic features.

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Kenneth O DevaneyAlfio Ferlito

Abstract

Head and neck lesions composed of spindle cells evoke a differential diagnosis which includes a host of benign and malignant entities. One of the less common spindle cell lesions in this region is the inflammatory myofibroblastic tumor (IMT). Although IMTs were originally regarded as "pseudotumors", they are now recognized to be true neoplasms. Local recurrence, and, rarely, malignant change have been reported. Currently, the definitive means of diagnosing IMTs is the identification of a rearrangement of the anaplastic lymphoma kinase gene (at chromosome 2p23) by fluorescence in situ hybridization. The histopathologic differential diagnosis includes infectious processes, other fibro-inflammatory lesions, lymphoma, the inflammatory variant of malignant fibrous histiocytoma, and sarcomatoid (spindle cell) carcinoma. Complete surgical excision is the treatment of choice.

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Citations

Jan 15, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Alfio FerlitoRobert P Takes
Nov 26, 2015·Journal of Endodontics·Makoto AdachiShinichiro Sumitomo
Dec 30, 2014·Head & Neck·Brian RodgersJames Lin
Sep 22, 2016·The Neuroradiology Journal·Sagar KansaraMark Zafereo
Aug 3, 2018·Head and Neck Pathology·A N FlamanB M Purgina
Aug 10, 2020·Indian Journal of Pathology & Microbiology·Vikender S YadavNitesh Tewari
Feb 2, 2021·British Journal of Neurosurgery·GengHuan WangLiTao Zhang
Aug 10, 2020·Journal of Pediatric Hematology/oncology·Karishma RaoGangaram Akangire

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